PHARMACEUTICAL COMPOSITIONS FOR USE IN TREATING PAIN

Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one li...

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Hauptverfasser: LIN, Yi-Yu, HONG, Keelung, TSENG, Yun-Long, TAI, Tien-Tzu, KUO, Min-Wen, BROWN, Carl, Oscar, SHIH, Sheue-Fang, WANG, Hui-Ting, JAO, Weenee, Yeun Ng, YU, Wan-Ni, HU, Pei-Hsien, KAO, Hao-Wen
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creator LIN, Yi-Yu
HONG, Keelung
TSENG, Yun-Long
TAI, Tien-Tzu
KUO, Min-Wen
BROWN, Carl, Oscar
SHIH, Sheue-Fang
WANG, Hui-Ting
JAO, Weenee, Yeun Ng
YU, Wan-Ni
HU, Pei-Hsien
KAO, Hao-Wen
description Provided is a pharmaceutical composition for use in treating postsurgical pain. The pharmaceutical composition comprises a lipid-based complex. The lipid-based complex comprises an amide-type anesthetic and at least one lipid, wherein a molar ratio of the amide-type anesthetic to the at least one lipid of the lipid-based complex is at least 0.5:1. The total amount of the amide-type anesthetic is at least 1.5 to 5 times of a standard therapeutic dose for treating postsurgical pain with the amide-type anesthetic to achieve an improved pain control with desired prolonged analgesic effect.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PHARMACEUTICAL COMPOSITIONS FOR USE IN TREATING PAIN
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