METHOD FOR SYNTHESIZING DOPA OLIGOPEPTIDE INTERMEDIATE AND USE, COMPOSITION AND PREPARATION THEREOF
This invention belongs to the medicine field and discloses a synthetic method of L-DOPA-containing oligopeptide derivatives and pharmaceutical applications. Specifically, it includes an improved synthesis of ketal-protected L-DOPA intermediates, the synthesis of fatty acid conjugates with L-DOPA-con...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | HE, Yanmiao ZHONG, Shibo LIU, Zhongqiang CHEN, Sikang HU, Bihuang ZHANG, Xiaoyan NING, Donghua WAN, Ying LI, Mengdi FAN, Lixia XIONG, Feng FU, Kaizhong YAO, Rui |
| description | This invention belongs to the medicine field and discloses a synthetic method of L-DOPA-containing oligopeptide derivatives and pharmaceutical applications. Specifically, it includes an improved synthesis of ketal-protected L-DOPA intermediates, the synthesis of fatty acid conjugates with L-DOPA-containing dipeptides using the above key intermediates. The said ketal-protected intermediate can be synthesized in two steps with high yields, eliminating the two steps of protection and deprotection of a carboxyl group used in the previous art. This intermediate was applied to synthesize many end products, and among them, FDD-16, FDD-18 and FDD-14 can form gels in a wide range of concentrations, which exhibit good stabilities and long half-lives and are promising to be developed into anti-parkinsonism drugs with high bioavailability and long-term controlled-release effect. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3929183A4</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3929183A4</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3929183A43</originalsourceid><addsrcrecordid>eNqNjDEKwkAQRdNYiHqHOYAWuhamXLKTZMDdGXbHQpsQwlqJBuL9UYIHsPq8x-Mvi8Gjtuyg5gjpGrTFRDcKDTgWC3ymhgVFySFQUIweHVlFsMHBJeEWKvbCiZQ4zFIiio125u9bRK7XxeLeP6a8-e2qgBq1and5fHV5GvshP_O7QzHlodyfjD2aP5IP5WM0Pg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>METHOD FOR SYNTHESIZING DOPA OLIGOPEPTIDE INTERMEDIATE AND USE, COMPOSITION AND PREPARATION THEREOF</title><source>esp@cenet</source><creator>HE, Yanmiao ; ZHONG, Shibo ; LIU, Zhongqiang ; CHEN, Sikang ; HU, Bihuang ; ZHANG, Xiaoyan ; NING, Donghua ; WAN, Ying ; LI, Mengdi ; FAN, Lixia ; XIONG, Feng ; FU, Kaizhong ; YAO, Rui</creator><creatorcontrib>HE, Yanmiao ; ZHONG, Shibo ; LIU, Zhongqiang ; CHEN, Sikang ; HU, Bihuang ; ZHANG, Xiaoyan ; NING, Donghua ; WAN, Ying ; LI, Mengdi ; FAN, Lixia ; XIONG, Feng ; FU, Kaizhong ; YAO, Rui</creatorcontrib><description>This invention belongs to the medicine field and discloses a synthetic method of L-DOPA-containing oligopeptide derivatives and pharmaceutical applications. Specifically, it includes an improved synthesis of ketal-protected L-DOPA intermediates, the synthesis of fatty acid conjugates with L-DOPA-containing dipeptides using the above key intermediates. The said ketal-protected intermediate can be synthesized in two steps with high yields, eliminating the two steps of protection and deprotection of a carboxyl group used in the previous art. This intermediate was applied to synthesize many end products, and among them, FDD-16, FDD-18 and FDD-14 can form gels in a wide range of concentrations, which exhibit good stabilities and long half-lives and are promising to be developed into anti-parkinsonism drugs with high bioavailability and long-term controlled-release effect.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221207&DB=EPODOC&CC=EP&NR=3929183A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20221207&DB=EPODOC&CC=EP&NR=3929183A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HE, Yanmiao</creatorcontrib><creatorcontrib>ZHONG, Shibo</creatorcontrib><creatorcontrib>LIU, Zhongqiang</creatorcontrib><creatorcontrib>CHEN, Sikang</creatorcontrib><creatorcontrib>HU, Bihuang</creatorcontrib><creatorcontrib>ZHANG, Xiaoyan</creatorcontrib><creatorcontrib>NING, Donghua</creatorcontrib><creatorcontrib>WAN, Ying</creatorcontrib><creatorcontrib>LI, Mengdi</creatorcontrib><creatorcontrib>FAN, Lixia</creatorcontrib><creatorcontrib>XIONG, Feng</creatorcontrib><creatorcontrib>FU, Kaizhong</creatorcontrib><creatorcontrib>YAO, Rui</creatorcontrib><title>METHOD FOR SYNTHESIZING DOPA OLIGOPEPTIDE INTERMEDIATE AND USE, COMPOSITION AND PREPARATION THEREOF</title><description>This invention belongs to the medicine field and discloses a synthetic method of L-DOPA-containing oligopeptide derivatives and pharmaceutical applications. Specifically, it includes an improved synthesis of ketal-protected L-DOPA intermediates, the synthesis of fatty acid conjugates with L-DOPA-containing dipeptides using the above key intermediates. The said ketal-protected intermediate can be synthesized in two steps with high yields, eliminating the two steps of protection and deprotection of a carboxyl group used in the previous art. This intermediate was applied to synthesize many end products, and among them, FDD-16, FDD-18 and FDD-14 can form gels in a wide range of concentrations, which exhibit good stabilities and long half-lives and are promising to be developed into anti-parkinsonism drugs with high bioavailability and long-term controlled-release effect.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAQRdNYiHqHOYAWuhamXLKTZMDdGXbHQpsQwlqJBuL9UYIHsPq8x-Mvi8Gjtuyg5gjpGrTFRDcKDTgWC3ymhgVFySFQUIweHVlFsMHBJeEWKvbCiZQ4zFIiio125u9bRK7XxeLeP6a8-e2qgBq1and5fHV5GvshP_O7QzHlodyfjD2aP5IP5WM0Pg</recordid><startdate>20221207</startdate><enddate>20221207</enddate><creator>HE, Yanmiao</creator><creator>ZHONG, Shibo</creator><creator>LIU, Zhongqiang</creator><creator>CHEN, Sikang</creator><creator>HU, Bihuang</creator><creator>ZHANG, Xiaoyan</creator><creator>NING, Donghua</creator><creator>WAN, Ying</creator><creator>LI, Mengdi</creator><creator>FAN, Lixia</creator><creator>XIONG, Feng</creator><creator>FU, Kaizhong</creator><creator>YAO, Rui</creator><scope>EVB</scope></search><sort><creationdate>20221207</creationdate><title>METHOD FOR SYNTHESIZING DOPA OLIGOPEPTIDE INTERMEDIATE AND USE, COMPOSITION AND PREPARATION THEREOF</title><author>HE, Yanmiao ; ZHONG, Shibo ; LIU, Zhongqiang ; CHEN, Sikang ; HU, Bihuang ; ZHANG, Xiaoyan ; NING, Donghua ; WAN, Ying ; LI, Mengdi ; FAN, Lixia ; XIONG, Feng ; FU, Kaizhong ; YAO, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3929183A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HE, Yanmiao</creatorcontrib><creatorcontrib>ZHONG, Shibo</creatorcontrib><creatorcontrib>LIU, Zhongqiang</creatorcontrib><creatorcontrib>CHEN, Sikang</creatorcontrib><creatorcontrib>HU, Bihuang</creatorcontrib><creatorcontrib>ZHANG, Xiaoyan</creatorcontrib><creatorcontrib>NING, Donghua</creatorcontrib><creatorcontrib>WAN, Ying</creatorcontrib><creatorcontrib>LI, Mengdi</creatorcontrib><creatorcontrib>FAN, Lixia</creatorcontrib><creatorcontrib>XIONG, Feng</creatorcontrib><creatorcontrib>FU, Kaizhong</creatorcontrib><creatorcontrib>YAO, Rui</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HE, Yanmiao</au><au>ZHONG, Shibo</au><au>LIU, Zhongqiang</au><au>CHEN, Sikang</au><au>HU, Bihuang</au><au>ZHANG, Xiaoyan</au><au>NING, Donghua</au><au>WAN, Ying</au><au>LI, Mengdi</au><au>FAN, Lixia</au><au>XIONG, Feng</au><au>FU, Kaizhong</au><au>YAO, Rui</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD FOR SYNTHESIZING DOPA OLIGOPEPTIDE INTERMEDIATE AND USE, COMPOSITION AND PREPARATION THEREOF</title><date>2022-12-07</date><risdate>2022</risdate><abstract>This invention belongs to the medicine field and discloses a synthetic method of L-DOPA-containing oligopeptide derivatives and pharmaceutical applications. Specifically, it includes an improved synthesis of ketal-protected L-DOPA intermediates, the synthesis of fatty acid conjugates with L-DOPA-containing dipeptides using the above key intermediates. The said ketal-protected intermediate can be synthesized in two steps with high yields, eliminating the two steps of protection and deprotection of a carboxyl group used in the previous art. This intermediate was applied to synthesize many end products, and among them, FDD-16, FDD-18 and FDD-14 can form gels in a wide range of concentrations, which exhibit good stabilities and long half-lives and are promising to be developed into anti-parkinsonism drugs with high bioavailability and long-term controlled-release effect.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3929183A4 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | METHOD FOR SYNTHESIZING DOPA OLIGOPEPTIDE INTERMEDIATE AND USE, COMPOSITION AND PREPARATION THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T19%3A24%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=HE,%20Yanmiao&rft.date=2022-12-07&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3929183A4%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |