FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR

A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.

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Hauptverfasser: SHANG, Ke, XU, Lingling, JIANG, Lei, JIN, Xian, XU, Yuan, ZHANG, Yuxing, SHOU, Jianyong, FENG, Zhiyong, WU, Danyi, QIAO, Zhi, ZHANG, Shuyun, ZHANG, Yi
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Sprache:eng ; fre ; ger
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creator SHANG, Ke
XU, Lingling
JIANG, Lei
JIN, Xian
XU, Yuan
ZHANG, Yuxing
SHOU, Jianyong
FENG, Zhiyong
WU, Danyi
QIAO, Zhi
ZHANG, Shuyun
ZHANG, Yi
description A class of five-membered fused with six-membered heterocyclic compounds represented by formula I and a pharmaceutical composition, preparation, and an application thereof are disclosed. These compounds have TRK kinase inhibitory activity and can treat diseases related to TRK dysfunction.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title FIVE-AND-SIX-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS PROTEIN RECEPTOR KINASE INHIBITOR
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