HTT REPRESSORS AND USES THEREOF

Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modul...

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Hauptverfasser: CHOI, Vivian, CHIOCCO, Matthew, REBAR, Edward, ZHANG, Lei, FELICE, Brian, MILLER, Jeffrey, PASCHON, David, KLATTE, Debra, ZEITLER, Bryan, FROELICH, Steven, CAREY, Galen, ZHANG, H. Steve
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creator CHOI, Vivian
CHIOCCO, Matthew
REBAR, Edward
ZHANG, Lei
FELICE, Brian
MILLER, Jeffrey
PASCHON, David
KLATTE, Debra
ZEITLER, Bryan
FROELICH, Steven
CAREY, Galen
ZHANG, H. Steve
description Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title HTT REPRESSORS AND USES THEREOF
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