METHOD FOR PREPARING DRUG TOXIN PNU-159682 OF ANTIBODY DRUG CONJUGATE, AND INTERMEDIATE THEREIN

METHOD FOR PREPARING DRUG TOXIN PNU-159682 OF ANTIBODY DRUG CONJUGATE, AND INTERMEDIATE THEREIN

The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GUI, Dong, LI, Hui, KONG, Lingpei, ZHANG, Binbin, CHEN, Yu, JIA, Zhongquan, XIA, Deyin, GUO, Maojun, LI, Haihong
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The disclosure provides a method for preparing drug toxin PNU-159682 (morpholinyl anthracycline derivative) for antibody-conjugated drugs and intermediates involved in the preparation method. The preparation method of the present disclosure improves the stability, practicability and scalability of the process by introducing protecting groups and changing to reagents that are capable to amplify; the preparation method of the present disclosure minimizes the risk and operational difficulty during scale-up production; production and operation is simple and convenient.