ANTIBODY-CONJUGATES FOR TARGETING OF TUMOURS EXPRESSING TROP-2

ANTIBODY-CONJUGATES FOR TARGETING OF TUMOURS EXPRESSING TROP-2

The present invention concerns antibody-conjugate having general structure (2):AB-[(L6)-{Z-(L1)n-(L2)o-(L3)p-(L4)q-D}xx]yy   (2)wherein AB is an antibody capable of targeting Trop-2-expressing tumours and D is selected from the group consisting of taxanes, anthracyclines, camptothecins, epothilones,...

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Hauptverfasser: VERKADE, Jorge Merijn Mathieu, WIJDEVEN, Maria Antonia, VAN DELFT, Floris Louis, HOOGENBOOM, Jorin, VAN BERKEL, Sander Sebastiaan, VAN DE SANDE, Petrus Josephus Jacobus Maria
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Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator VERKADE, Jorge Merijn Mathieu
WIJDEVEN, Maria Antonia
VAN DELFT, Floris Louis
HOOGENBOOM, Jorin
VAN BERKEL, Sander Sebastiaan
VAN DE SANDE, Petrus Josephus Jacobus Maria
description The present invention concerns antibody-conjugate having general structure (2):AB-[(L6)-{Z-(L1)n-(L2)o-(L3)p-(L4)q-D}xx]yy   (2)wherein AB is an antibody capable of targeting Trop-2-expressing tumours and D is selected from the group consisting of taxanes, anthracyclines, camptothecins, epothilones, mytomycins, combretastatins, vinca alkaloids, maytansinoids, enediynes such as calicheamicins, duocarmycins, tubulysins, amatoxins, bleomycins, dolastatins and auristatins, pyrrolobenzodiazepine dimers, indolinobenzodiazepine dimers, radioisotopes, therapeutic proteins and peptides (or fragments thereof), kinase inhibitors, MEK inhibitors, KSP inhibitors, and analogues or prodrugs thereof. These antibody-conjugates exhibit an improved therapeutic index. The invention further concerns a process for preparing the antibody-conjugate according to the invention, a method for targeting Trop-2-expressing cells, medical uses of the antibody-conjugates according to the invention.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTIBODY-CONJUGATES FOR TARGETING OF TUMOURS EXPRESSING TROP-2
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