CYTOSTATIC CONJUGATES WITH INTEGRIN LIGANDS

The present invention relates to novel pharmaceutical compounds comprising of an αvβ3 integrin antagonist, a linking unit comprising of L-Val-L-Pro-L-Asp cleavable by elastase, a polyethylene glycol (PEG) spacer and a cytotoxic element, to processes for preparation thereof, to the use thereof for tr...

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Bibliographische Detailangaben
Hauptverfasser:	LERCHEN, Hans-Georg, STELTE-LUDWIG, Beatrix, KOPITZ, Charlotte, Christine
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel pharmaceutical compounds comprising of an αvβ3 integrin antagonist, a linking unit comprising of L-Val-L-Pro-L-Asp cleavable by elastase, a polyethylene glycol (PEG) spacer and a cytotoxic element, to processes for preparation thereof, to the use thereof for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.