ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4 C...
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| creator | FENG, Lei LI, Jia ZHONG, Yuhua TIAN, Hongtao XU, Gaoya CHENG, Yu MI, Tian HU, Xiaobei ZHOU, Yubo ZHOU, Binshan NIE, Huijun CHEN, Xiaohua YAN, Kenian WANG, Yujie KAN, Weijuan |
| description | The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4 CRBN E3 ubiquitin ligase modulators in structure, wherein same has a stronger antitumor activity and antitumor spectrum, and can be used to prepare drugs for treating CRL4CRBN E3 ligase-related diseases. |
| format | Patent |
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In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4 CRBN E3 ubiquitin ligase modulators in structure, wherein same has a stronger antitumor activity and antitumor spectrum, and can be used to prepare drugs for treating CRL4CRBN E3 ligase-related diseases.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220622&DB=EPODOC&CC=EP&NR=3862348A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,782,887,25571,76555</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220622&DB=EPODOC&CC=EP&NR=3862348A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FENG, Lei</creatorcontrib><creatorcontrib>LI, Jia</creatorcontrib><creatorcontrib>ZHONG, Yuhua</creatorcontrib><creatorcontrib>TIAN, Hongtao</creatorcontrib><creatorcontrib>XU, Gaoya</creatorcontrib><creatorcontrib>CHENG, Yu</creatorcontrib><creatorcontrib>MI, Tian</creatorcontrib><creatorcontrib>HU, Xiaobei</creatorcontrib><creatorcontrib>ZHOU, Yubo</creatorcontrib><creatorcontrib>ZHOU, Binshan</creatorcontrib><creatorcontrib>NIE, Huijun</creatorcontrib><creatorcontrib>CHEN, Xiaohua</creatorcontrib><creatorcontrib>YAN, Kenian</creatorcontrib><creatorcontrib>WANG, Yujie</creatorcontrib><creatorcontrib>KAN, Weijuan</creatorcontrib><title>ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF</title><description>The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
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