METHODS OF TREATING CANCER WITH SMALL MOLECULE PD-L1 INHIBITORS

The present disclosure provides, inter alia, methods of treating cancer by administering an effective amount of a com-pound of Formula (I). In some embodiments, the cancer is a solid cancer. In some embodiments, the cancer is melanoma. In some aspects, the present disclosure provides methods of incr...

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Hauptverfasser: PUNNA, Sreenivas, SINGH, Rajinder, ZHANG, Penglie, VILALTA-COLOMER, Marta, MALATHONG, Viengkham, LI, Shijie
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creator PUNNA, Sreenivas
SINGH, Rajinder
ZHANG, Penglie
VILALTA-COLOMER, Marta
MALATHONG, Viengkham
LI, Shijie
description The present disclosure provides, inter alia, methods of treating cancer by administering an effective amount of a com-pound of Formula (I). In some embodiments, the cancer is a solid cancer. In some embodiments, the cancer is melanoma. In some aspects, the present disclosure provides methods of increasing the CD8+ T cell/CD4+ T cell ratio in a solid tumor microenvironment by administering an effective amount of a compound of Formula (I).
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title METHODS OF TREATING CANCER WITH SMALL MOLECULE PD-L1 INHIBITORS
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