DRUG COMBINATION OF QUINOLINE DERIVATIVE AND ANTIBODY

DRUG COMBINATION OF QUINOLINE DERIVATIVE AND ANTIBODY

The present application provides a therapeutic combination of a quinoline derivative and an antibody, which comprises an immune checkpoint inhibitor and a tyrosine kinase inhibitor, wherein the tyrosine kinase inhibitor is a compound of formula I or a pharmaceutically acceptable salt thereof. The th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LYU, Peng, XIA, Yu, LI, Baiyong, HAN, Baohui, SHEN, Chen, CHU, Tianqing, WANG, Xiangjian, WANG, Zhongmin Maxwell, LIU, Zheng, TIAN, Xin, LI, Rong, ZHONG, Hua, ZHANG, Xiquan, JIN, Xiaoping
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present application provides a therapeutic combination of a quinoline derivative and an antibody, which comprises an immune checkpoint inhibitor and a tyrosine kinase inhibitor, wherein the tyrosine kinase inhibitor is a compound of formula I or a pharmaceutically acceptable salt thereof. The therapeutic combination in the present application shows good activity against lung tumor and liver tumor.