PROCESSING METHOD FOR RAW DRUG PARTICLES OF NON-UNIFORM PARTICLE SIZE

PROCESSING METHOD FOR RAW DRUG PARTICLES OF NON-UNIFORM PARTICLE SIZE

The present invention relates to a pre-processing method for the purpose of formulating a drug substance having non-uniform particle sizes by a manufacturing method having excellent manufacture performance. According to the pre-processing method of the present invention, additives including at least...

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Hauptverfasser: SHIMOAKA, Kaori, KOMAI, Kunio, FUKUDA, Kiyoshi, SAKAMOTO, Hiroshi, NAMBA, Kensuke
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator SHIMOAKA, Kaori
KOMAI, Kunio
FUKUDA, Kiyoshi
SAKAMOTO, Hiroshi
NAMBA, Kensuke
description The present invention relates to a pre-processing method for the purpose of formulating a drug substance having non-uniform particle sizes by a manufacturing method having excellent manufacture performance. According to the pre-processing method of the present invention, additives including at least a dispersant are blended in a drug substance having a specific particle size distribution and then the resultant mixture is deagglomerated/sized to disperse and make adhere the additives onto the surfaces of the particles of the drug substance, thereby yielding a powder having a specified particle size distribution. In this manner, a pharmaceutical preparation can be manufactured with excellent manufacture performance, manufacture efficiency, and manufacture cost by a direct compression method, a wet continuous granulation system or the like. Therefore, the pre-processing method is very useful.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PROCESSING METHOD FOR RAW DRUG PARTICLES OF NON-UNIFORM PARTICLE SIZE
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