PCSK9 ANTAGONIST BICYCLO-COMPOUNDS

Disclosed are compounds of Formula I, or a salt thereof cyclic polypeptide of Formula I: Formula I where A, B, E, R4, and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their sa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	BIANCHI, Elisabetta, KEREKES, Angela, Dawn, XIONG, Yusheng, DING, Fa-Xiang, TUCKER, Thomas, Joseph, WU, Chengwei, BRANCA, Danila, INGENITO, Raffaele, YOUM, Hyewon, JOSIEN, Hubert, B, WALJI, Abbas, M, SANTOPRETE, Alessia
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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