METHODS FOR CONTROLLING LIMITATION CONDITIONS IN PRODUCT BIOSYNTHESIS FOR NON-PHB GENERATING CUPRIAVIDUS OR RALSTONIA
Provided herein are methods for increasing the yield of an extracellular product synthesized by an organism cultured in a continuous aerobic fermentation system. The extracellular product yield is increased through the use of an organism modified to decreased production of polyhydroxyalkanoate, to i...
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| creator | BAWDON, Daniel TAYLOR, Mark Paul COMBE, Jonathan AMATRIAIN, Cristina Serrano PEARLMAN, Paul Sheldon FOSTER, Alexander Brett SMITH, Gary J |
| description | Provided herein are methods for increasing the yield of an extracellular product synthesized by an organism cultured in a continuous aerobic fermentation system. The extracellular product yield is increased through the use of an organism modified to decreased production of polyhydroxyalkanoate, to increase production of the extracellular product, and to include promoters that can be inducible in response to nutrient limitation conditions. The extracellular product yield is also increased by operating the continuous fermentation system under particular nutrient limitation conditions. Also provided are non-naturally occurring organisms that have been modified for use with the provided methods, and extracellular products made using the provided methods. |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE |
| title | METHODS FOR CONTROLLING LIMITATION CONDITIONS IN PRODUCT BIOSYNTHESIS FOR NON-PHB GENERATING CUPRIAVIDUS OR RALSTONIA |
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