SELECTIVE ENRICHMENT OF HIGH-QUALITY DNA INTACT SPERMS FROM A SEMEN SAMPLE

SELECTIVE ENRICHMENT OF HIGH-QUALITY DNA INTACT SPERMS FROM A SEMEN SAMPLE

Disclosed is a composition for selective enrichment of progressively motile non-fragmented/intact DNA sperms during swim-up of semen sample comprising combination of electrolytes, a mix of excipients, polyyvinylpyrrolidone, recombinant human serum albumin or bovine serum albumin. A method of selecti...

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Hauptverfasser: SOMAN, Jay Laxman, MOTUKURI, Mahesh, SOMAN, Raunak Jay
Format: Patent
Sprache:eng ; fre ; ger
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator SOMAN, Jay Laxman
MOTUKURI, Mahesh
SOMAN, Raunak Jay
description Disclosed is a composition for selective enrichment of progressively motile non-fragmented/intact DNA sperms during swim-up of semen sample comprising combination of electrolytes, a mix of excipients, polyyvinylpyrrolidone, recombinant human serum albumin or bovine serum albumin. A method of selective enrichment of DNA-intact sperms using the compositions of the present invention is also disclosed. The DNA fragmentation index of the swim-up sperms are less than the DNA fragmentation index of the neat samples. The media compositions of the present invention are applicable for enrichment of non-fragmented/intact DNA sperms for therapeutic purposes in the field of assisted reproductive technologies.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title SELECTIVE ENRICHMENT OF HIGH-QUALITY DNA INTACT SPERMS FROM A SEMEN SAMPLE
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