ANTI-CXCR4 ANTIBODY COMBINED WITH ACTIVATED AND EXPANDED NATURAL KILLER CELLS FOR CANCER IMMUNOTHERAPY

This disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a combination of therapeutically effective amounts of an isolated population of natural killer (NK) cells, preferably activated and expanded NK (NKAE) cells, and an antibody or an...

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Bibliographische Detailangaben
Hauptverfasser:	PÉREZ MARTÍNEZ, Antonio, VALENTÌN QUIROGA, Jaime, FERNÁNDEZ CASANOVA, Lucía, VELA CUENCA, María, ESCUDERO LÓPEZ, Adela, GONZÀLEZ NAVARRO, Pablo
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This disclosure provides a method for treating a subject afflicted with a cancer comprising administering to the subject a combination of therapeutically effective amounts of an isolated population of natural killer (NK) cells, preferably activated and expanded NK (NKAE) cells, and an antibody or an antigen-binding portion thereof that binds specifically to C-X-C Chemokine Receptor 4 (CXCR4) expressed on the surface of a cancer cell.