MEMANTINE PAROXETINE COCRYSTAL SALT AND ITS PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND APPLICATION
The invention discloses a memantine paroxetine cocrystal salt and its preparation method, pharmaceutical composition and application thereof. The cocrystal salt of the invention is memantine paroxetine sulfate hydrate. Its mechanism of action is 5-HT inhibitor and NMDA receptor antagonist. It is a m...
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| creator | ZHAO, Xun WANG, Ke WANG, Zonggui CHENG, Qianliu WANG, Gang GENG, Yan |
| description | The invention discloses a memantine paroxetine cocrystal salt and its preparation method, pharmaceutical composition and application thereof. The cocrystal salt of the invention is memantine paroxetine sulfate hydrate. Its mechanism of action is 5-HT inhibitor and NMDA receptor antagonist. It is a multi-target drug. The preliminary pharmacokinetic experiments showed that the main pharmacokinetic parameters of cocrystal salt and memantine, such as t1/2, Tmax, Cmax and AUC(0-∞), were significantly different. The results also showed that cocrystal salt could improve drug absorption, blood drug concentration, bioavailability and curative effect. This provides a material basis for reducing dosage and adverse drug reactions. In addition to that the cocrystal salt of this invention can be used as a multi-target drug, it can also combine with other drugs of different action mechanisms to form compound preparations or be used in combination, so as to obtain unexpected clinical efficacy. |
| format | Patent |
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The cocrystal salt of the invention is memantine paroxetine sulfate hydrate. Its mechanism of action is 5-HT inhibitor and NMDA receptor antagonist. It is a multi-target drug. The preliminary pharmacokinetic experiments showed that the main pharmacokinetic parameters of cocrystal salt and memantine, such as t1/2, Tmax, Cmax and AUC(0-∞), were significantly different. The results also showed that cocrystal salt could improve drug absorption, blood drug concentration, bioavailability and curative effect. This provides a material basis for reducing dosage and adverse drug reactions. 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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MEMANTINE PAROXETINE COCRYSTAL SALT AND ITS PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND APPLICATION |
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