ENHANCED IMMUNE CELLS USING DUAL SHRNA AND COMPOSITION INCLUDING THE SAME

The present invention relates to a vector comprising: a) a base sequence encoding two types of short hairpin RNA (shRNA), which inhibit the expression of at least one gene that weakens the function of immune cells, and b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, Yujean, KIM, Chan Hyuk, LEE, Young-Ho, LEE, Sang Hoon, LEE, HyeongJi
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a vector comprising: a) a base sequence encoding two types of short hairpin RNA (shRNA), which inhibit the expression of at least one gene that weakens the function of immune cells, and b) a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular antigen recognition domain, a transmembrane domain, and an intracellular signal transduction domain.