NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS
The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large sc...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NAKAI, Takashi XUE, Song WALLACE, Debra Jane WANG, Yuguang SCHAIRER, Wayne C KISSEL, William HASHASH, Ahmad ZHOU, Fenger KARNATI, Vishnu Vardhan Reddy |
| description | The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3737679A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3737679A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3737679A13</originalsourceid><addsrcrecordid>eNqNyrEKwjAQgOEuDqK-w72AgwQMjmd6sYE0V3Kp0MVSJE6ihfr-mMEHcPrh51tXt8BX8tBFNiRCAhhqcCFRbKl2mMqxHCE1VAx1GDE5DsAWhH1_9gSXHsPgiwQzGI9CIMm1fTkcZVutHtNzybtfNxVYSqbZ5_k95mWe7vmVPyN1Sit91Cc8qD_IF-2FMwo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS</title><source>esp@cenet</source><creator>NAKAI, Takashi ; XUE, Song ; WALLACE, Debra Jane ; WANG, Yuguang ; SCHAIRER, Wayne C ; KISSEL, William ; HASHASH, Ahmad ; ZHOU, Fenger ; KARNATI, Vishnu Vardhan Reddy</creator><creatorcontrib>NAKAI, Takashi ; XUE, Song ; WALLACE, Debra Jane ; WANG, Yuguang ; SCHAIRER, Wayne C ; KISSEL, William ; HASHASH, Ahmad ; ZHOU, Fenger ; KARNATI, Vishnu Vardhan Reddy</creatorcontrib><description>The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.</description><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201118&DB=EPODOC&CC=EP&NR=3737679A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201118&DB=EPODOC&CC=EP&NR=3737679A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NAKAI, Takashi</creatorcontrib><creatorcontrib>XUE, Song</creatorcontrib><creatorcontrib>WALLACE, Debra Jane</creatorcontrib><creatorcontrib>WANG, Yuguang</creatorcontrib><creatorcontrib>SCHAIRER, Wayne C</creatorcontrib><creatorcontrib>KISSEL, William</creatorcontrib><creatorcontrib>HASHASH, Ahmad</creatorcontrib><creatorcontrib>ZHOU, Fenger</creatorcontrib><creatorcontrib>KARNATI, Vishnu Vardhan Reddy</creatorcontrib><title>NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS</title><description>The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w72AgwQMjmd6sYE0V3Kp0MVSJE6ihfr-mMEHcPrh51tXt8BX8tBFNiRCAhhqcCFRbKl2mMqxHCE1VAx1GDE5DsAWhH1_9gSXHsPgiwQzGI9CIMm1fTkcZVutHtNzybtfNxVYSqbZ5_k95mWe7vmVPyN1Sit91Cc8qD_IF-2FMwo</recordid><startdate>20201118</startdate><enddate>20201118</enddate><creator>NAKAI, Takashi</creator><creator>XUE, Song</creator><creator>WALLACE, Debra Jane</creator><creator>WANG, Yuguang</creator><creator>SCHAIRER, Wayne C</creator><creator>KISSEL, William</creator><creator>HASHASH, Ahmad</creator><creator>ZHOU, Fenger</creator><creator>KARNATI, Vishnu Vardhan Reddy</creator><scope>EVB</scope></search><sort><creationdate>20201118</creationdate><title>NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS</title><author>NAKAI, Takashi ; XUE, Song ; WALLACE, Debra Jane ; WANG, Yuguang ; SCHAIRER, Wayne C ; KISSEL, William ; HASHASH, Ahmad ; ZHOU, Fenger ; KARNATI, Vishnu Vardhan Reddy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3737679A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2020</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>NAKAI, Takashi</creatorcontrib><creatorcontrib>XUE, Song</creatorcontrib><creatorcontrib>WALLACE, Debra Jane</creatorcontrib><creatorcontrib>WANG, Yuguang</creatorcontrib><creatorcontrib>SCHAIRER, Wayne C</creatorcontrib><creatorcontrib>KISSEL, William</creatorcontrib><creatorcontrib>HASHASH, Ahmad</creatorcontrib><creatorcontrib>ZHOU, Fenger</creatorcontrib><creatorcontrib>KARNATI, Vishnu Vardhan Reddy</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NAKAI, Takashi</au><au>XUE, Song</au><au>WALLACE, Debra Jane</au><au>WANG, Yuguang</au><au>SCHAIRER, Wayne C</au><au>KISSEL, William</au><au>HASHASH, Ahmad</au><au>ZHOU, Fenger</au><au>KARNATI, Vishnu Vardhan Reddy</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS</title><date>2020-11-18</date><risdate>2020</risdate><abstract>The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3737679A1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T13%3A51%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NAKAI,%20Takashi&rft.date=2020-11-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3737679A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |