NON-COVALENTLY ASSEMBLED BIOMATRIX LAYER
The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 µM to 250 µM and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n(I) wher...
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| creator | ZHANG, Yixin WIEDUWILD, Robert WETZEL, Richard THOMAS, Alvin HUSMAN, Dejan |
| description | The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 µM to 250 µM and a peptide-polyethylene glycol-conjugate according to formula (I):
PEG-R1-(BX)n(I)
wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R 1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 µM to 250 µM ; R1, if present, is comprised at a concentration in the range of 0.1 µM to 1000 µM; (BX)n is comprised at a concentration in the range of 0.25 µM to 250 µM. The invention further relates to processes for assembling the biomatrix layer. The biomatrix layer can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery. |
| format | Patent |
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PEG-R1-(BX)n(I)
wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R 1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 µM to 250 µM ; R1, if present, is comprised at a concentration in the range of 0.1 µM to 1000 µM; (BX)n is comprised at a concentration in the range of 0.25 µM to 250 µM. The invention further relates to processes for assembling the biomatrix layer. The biomatrix layer can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.</description><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200422&DB=EPODOC&CC=EP&NR=3638313A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200422&DB=EPODOC&CC=EP&NR=3638313A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG, Yixin</creatorcontrib><creatorcontrib>WIEDUWILD, Robert</creatorcontrib><creatorcontrib>WETZEL, Richard</creatorcontrib><creatorcontrib>THOMAS, Alvin</creatorcontrib><creatorcontrib>HUSMAN, Dejan</creatorcontrib><title>NON-COVALENTLY ASSEMBLED BIOMATRIX LAYER</title><description>The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 µM to 250 µM and a peptide-polyethylene glycol-conjugate according to formula (I):
PEG-R1-(BX)n(I)
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PEG-R1-(BX)n(I)
wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; R 1 may be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 µM to 250 µM ; R1, if present, is comprised at a concentration in the range of 0.1 µM to 1000 µM; (BX)n is comprised at a concentration in the range of 0.25 µM to 250 µM. The invention further relates to processes for assembling the biomatrix layer. The biomatrix layer can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | NON-COVALENTLY ASSEMBLED BIOMATRIX LAYER |
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