LIPIDIC NANOPARTICLES FOR MRNA DELIVERY IN THE LUNGS

LIPIDIC NANOPARTICLES FOR MRNA DELIVERY IN THE LUNGS

Disclosed herein are compositions for modulating the production of a protein in a target cell, in particular for ameliorating diseases associated with protein or enzyme deficiencies. The compositions comprise at least one mRNA encoding a polypeptide of interest, and a transfer vehicle comprising a l...

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Hauptverfasser: DEROSA, Frank, GUILD, Braydon, Charles, HEARTLEIN, Michael
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator DEROSA, Frank
GUILD, Braydon, Charles
HEARTLEIN, Michael
description Disclosed herein are compositions for modulating the production of a protein in a target cell, in particular for ameliorating diseases associated with protein or enzyme deficiencies. The compositions comprise at least one mRNA encoding a polypeptide of interest, and a transfer vehicle comprising a lipid nanoparticle or a lipidoid nanoparticle.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title LIPIDIC NANOPARTICLES FOR MRNA DELIVERY IN THE LUNGS
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