NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF
Novel TRF1 modulators and analogues thereof.There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell ca...
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| creator | BEJARANO BOSQUE, Leire VARELA BUSTO, Carmen PASTOR FERNANDEZ, Joaquin Angel BLASCO MARHUENDA, Maria Antonia BLANCO-APARICIO, Carmen GOMEZ-CASERO ESTEBAN, Elena GARCIA-BECCARIA, Maria MARTINEZ RODRIGUEZ, Paula MARTINEZ GONZALEZ, Sonia MENDEZ PERTUZ, Marinela GARCIA GARCIA, Ana Belen |
| description | Novel TRF1 modulators and analogues thereof.There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL TRF1 MODULATORS AND ANALOGUES THEREOF |
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