MONOCLONAL ANTIBODY ANTAGONIZING AND INHIBITING BINDING BETWEEN HUMAN PD-1 ANTIGEN AND LIGAND THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Disclosed in the present invention is a monoclonal antibody or a derivative thereof which can antagonize and inhibit the binding of human PD-1 antigen to its ligand: the amino acid sequences of CDR1, CDR 2 and CDR 3 in the light chain variable region of the antibody are shown in SEQ ID NO:3, SEQ ID...
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| creator | HU, Hongqun ZHOU, Qunmin CHEN, Zui XU, Yiqing CAI, Mingwen LUO, Shiping FAN, Jinling SONG, Xiaoqi |
| description | Disclosed in the present invention is a monoclonal antibody or a derivative thereof which can antagonize and inhibit the binding of human PD-1 antigen to its ligand: the amino acid sequences of CDR1, CDR 2 and CDR 3 in the light chain variable region of the antibody are shown in SEQ ID NO:3, SEQ ID NO: 4 and SEQ ID NO: 5, respectively, while the amino acid sequences of CDR 1, CDR 2 and CDR 3 in the heavy chain variable region are shown in SEQ ID NO: 8, SEQ ID NO: 9 and SEQ ID NO: 10, respectively. Further disclosed are a humanization preparation process for the antibody and the amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody. The antibody or a derivative thereof can be used as a component of pharmaceutical composition or an appropriate pharmaceutic preparation either alone or in combination with other treatments such as chemotherapeutics to cure colon cancer and other solid tumors. |
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Further disclosed are a humanization preparation process for the antibody and the amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody. 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Further disclosed are a humanization preparation process for the antibody and the amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody. 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Further disclosed are a humanization preparation process for the antibody and the amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody. The antibody or a derivative thereof can be used as a component of pharmaceutical composition or an appropriate pharmaceutic preparation either alone or in combination with other treatments such as chemotherapeutics to cure colon cancer and other solid tumors.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | MONOCLONAL ANTIBODY ANTAGONIZING AND INHIBITING BINDING BETWEEN HUMAN PD-1 ANTIGEN AND LIGAND THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF |
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