PROLINE AMIDE COMPOUNDS AND THEIR AZETIDINE ANALOGUES CARRYING A SPECIFICALLY SUBSTITUTED BENZYL RADICAL

The present invention relates to proline amide compounds and their azetidine derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especiall...

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Hauptverfasser: KLING, Andreas, BACKFISCH, Gisela, ERHARD, Thomas, BAKKER, Margaretha, BRAJE, Wilfried, HOFT, Carolin, RELO, Ana Lucia, OELLIEN, Frank, BLACK, Lawrence, DRESCHER, Karla, LAKICS, Viktor, HAUPT, Andreas, MACK, Helmut
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to proline amide compounds and their azetidine derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of the 5-HT2C receptor, and processes for preparing such compounds and compositions.