MUTANT HISTIDINE DECARBOXYLASE AND USE THEREOF

The present invention provides a mutated histidine decarboxylase suitable for a practical use. Specifically, the present invention provides a mutated histidine decarboxylase having at least one amino acid residue of a wild-type histidine decarboxylase mutated and having higher histidine decarboxylase activity and/or stability than the wild-type histidine decarboxylase, and also a use thereof. The mutated histidine decarboxylase has Motifs (1) to (6), and preferably an amino acid residue in at least one motif thereof is mutated. The mutated histidine decarboxylase is also preferred to have mutation of at least one amino acid residue in an amino acid sequence designated by SEQ ID NO: 3 and in a homologous sequence thereto.