COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY
Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chim...
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| creator | BEAUCHESNE, Pascal YEE, Nathan MALLANEY, Mary WEBER, Clinton LI, He LAMBERT, Nathaniel POLLOCK, Kathryn Lindsay SMITH, Jeff GILBERT, Mark LARSON, Ryan P KOWSKI, Tom WALKER, Andrew W SUTHERLAND, Claire CHRISTIN, Brian BECKETT, Travis TREDE, Nikolaus Sebastian RAMSBORG, Christopher Glen COVINGTON, Michael Gerard WHITMORE, James Boyd DAVIS-PICKETT, Mel DAVE, Kedar Himanshu ODEGARD, Valerie BLACKMAN, Samuel Charles CHARTRAND, Nathaniel GETTO, Richard James, Jr |
| description | Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions. |
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The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). 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The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNy7EKwjAQgOEuDqK-wz2AgrQWXI_kYgJJLiTXwakUiZNoob4_OvgATv_y_eumKA6JixPHsewBszjlqQAbCBgHg0qGTIBRQyCxrAtk8iikQRj094wXcBEUeQ9iKWO6bpvVfXosdffrpgFDouyhzq-xLvN0q8_6Hil1_bk_HVtsuz_IB5yVL1c</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>BEAUCHESNE, Pascal</creator><creator>YEE, Nathan</creator><creator>MALLANEY, Mary</creator><creator>WEBER, Clinton</creator><creator>LI, He</creator><creator>LAMBERT, Nathaniel</creator><creator>POLLOCK, Kathryn Lindsay</creator><creator>SMITH, Jeff</creator><creator>GILBERT, Mark</creator><creator>LARSON, Ryan P</creator><creator>KOWSKI, Tom</creator><creator>WALKER, Andrew W</creator><creator>SUTHERLAND, Claire</creator><creator>CHRISTIN, Brian</creator><creator>BECKETT, Travis</creator><creator>TREDE, Nikolaus Sebastian</creator><creator>RAMSBORG, Christopher Glen</creator><creator>COVINGTON, Michael Gerard</creator><creator>WHITMORE, James Boyd</creator><creator>DAVIS-PICKETT, Mel</creator><creator>DAVE, Kedar Himanshu</creator><creator>ODEGARD, Valerie</creator><creator>BLACKMAN, Samuel Charles</creator><creator>CHARTRAND, Nathaniel</creator><creator>GETTO, Richard James, Jr</creator><scope>EVB</scope></search><sort><creationdate>20200101</creationdate><title>COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY</title><author>BEAUCHESNE, Pascal ; 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The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY |
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