COMPOSITIONS, ARTICLES OF MANUFACTURE AND METHODS RELATED TO DOSING IN CELL THERAPY

Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chim...

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Bibliographische Detailangaben
Hauptverfasser:	BEAUCHESNE, Pascal, YEE, Nathan, MALLANEY, Mary, WEBER, Clinton, LI, He, LAMBERT, Nathaniel, POLLOCK, Kathryn Lindsay, SMITH, Jeff, GILBERT, Mark, LARSON, Ryan P, KOWSKI, Tom, WALKER, Andrew W, SUTHERLAND, Claire, CHRISTIN, Brian, BECKETT, Travis, TREDE, Nikolaus Sebastian, RAMSBORG, Christopher Glen, COVINGTON, Michael Gerard, WHITMORE, James Boyd, DAVIS-PICKETT, Mel, DAVE, Kedar Himanshu, ODEGARD, Valerie, BLACKMAN, Samuel Charles, CHARTRAND, Nathaniel, GETTO, Richard James, Jr
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.