PLANT EXTRACTS ENRICHED WITH IPOLAMIIDE DERIVATIVES AS IMMUNOSUPPRESSANTS FOR TREATING IMMUNOLOGICAL DISORDERS

The present invention discloses enriched extracts from plants of the genus Stachytarpheta comprising ipolamiide and compounds of the formulae (I), (II) and/or (III):Such extracts could be useful to block activation of CD8+ T cells and reduce secretion of IFNgamma. They could have immunosuppressive a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GUIMARÃES, Cristiano Ruch Werneck, VITOR, Carlos Eduardo, PESSA, Lisandra Ravanelli, MASCARELLO, Alessandra, REIS, Romulo Dragani, GAMA, Fernando Henrique De Souza
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention discloses enriched extracts from plants of the genus Stachytarpheta comprising ipolamiide and compounds of the formulae (I), (II) and/or (III):Such extracts could be useful to block activation of CD8+ T cells and reduce secretion of IFNgamma. They could have immunosuppressive activity and could be useful in methods of treatment of immunological disorders and vitiligo.Preferred compounds of formulae (I), (II) and (III) are compounds of the formulae (IV) to (XI):Additionally the extracts preferably contain also compounds of the formulae (XII) to (XVI):