PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SOLID STATE FORMS OF REMIMAZOLAM SALTS
The present disclosure relates to novel processes for the preparation of short acting benzodiazepines as well as to novel intermediates in this process. More particularly the disclosure relates to processes and intermediates for preparation of Methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imid...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MARIOARA, Mendelovici VIJAY, Joshi Ashutosh BEN-ZION, Dolitzky RAJARAM, Bodkhe Arjun SRIHARI, Samala Rajamouli LUTHRA, Parven Kumar MUTHUSAMY, Anantha Rajmohan SINGH, Amit SHIVAJI, Mane Ganesh |
| description | The present disclosure relates to novel processes for the preparation of short acting benzodiazepines as well as to novel intermediates in this process. More particularly the disclosure relates to processes and intermediates for preparation of Methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate, commonly known as Remimazolam. The present disclosure also relates to solid state forms of Remimazolam salts, processes for the preparation thereof, pharmaceutical formulations / compositions thereof, and methods of use thereof. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3580219A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3580219A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3580219A13</originalsourceid><addsrcrecordid>eNrjZAgNCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTCHL19fR1jPL3cfRVcPRzUQj29_EEkiGOIa4gLb7B6IqCHX1CgnkYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgLGphYGRoaWjoTERSgAECzAL</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SOLID STATE FORMS OF REMIMAZOLAM SALTS</title><source>esp@cenet</source><creator>MARIOARA, Mendelovici ; VIJAY, Joshi Ashutosh ; BEN-ZION, Dolitzky ; RAJARAM, Bodkhe Arjun ; SRIHARI, Samala Rajamouli ; LUTHRA, Parven Kumar ; MUTHUSAMY, Anantha Rajmohan ; SINGH, Amit ; SHIVAJI, Mane Ganesh</creator><creatorcontrib>MARIOARA, Mendelovici ; VIJAY, Joshi Ashutosh ; BEN-ZION, Dolitzky ; RAJARAM, Bodkhe Arjun ; SRIHARI, Samala Rajamouli ; LUTHRA, Parven Kumar ; MUTHUSAMY, Anantha Rajmohan ; SINGH, Amit ; SHIVAJI, Mane Ganesh</creatorcontrib><description>The present disclosure relates to novel processes for the preparation of short acting benzodiazepines as well as to novel intermediates in this process. More particularly the disclosure relates to processes and intermediates for preparation of Methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate, commonly known as Remimazolam. The present disclosure also relates to solid state forms of Remimazolam salts, processes for the preparation thereof, pharmaceutical formulations / compositions thereof, and methods of use thereof.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191218&DB=EPODOC&CC=EP&NR=3580219A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191218&DB=EPODOC&CC=EP&NR=3580219A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARIOARA, Mendelovici</creatorcontrib><creatorcontrib>VIJAY, Joshi Ashutosh</creatorcontrib><creatorcontrib>BEN-ZION, Dolitzky</creatorcontrib><creatorcontrib>RAJARAM, Bodkhe Arjun</creatorcontrib><creatorcontrib>SRIHARI, Samala Rajamouli</creatorcontrib><creatorcontrib>LUTHRA, Parven Kumar</creatorcontrib><creatorcontrib>MUTHUSAMY, Anantha Rajmohan</creatorcontrib><creatorcontrib>SINGH, Amit</creatorcontrib><creatorcontrib>SHIVAJI, Mane Ganesh</creatorcontrib><title>PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SOLID STATE FORMS OF REMIMAZOLAM SALTS</title><description>The present disclosure relates to novel processes for the preparation of short acting benzodiazepines as well as to novel intermediates in this process. More particularly the disclosure relates to processes and intermediates for preparation of Methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate, commonly known as Remimazolam. The present disclosure also relates to solid state forms of Remimazolam salts, processes for the preparation thereof, pharmaceutical formulations / compositions thereof, and methods of use thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAgNCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTCHL19fR1jPL3cfRVcPRzUQj29_EEkiGOIa4gLb7B6IqCHX1CgnkYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgLGphYGRoaWjoTERSgAECzAL</recordid><startdate>20191218</startdate><enddate>20191218</enddate><creator>MARIOARA, Mendelovici</creator><creator>VIJAY, Joshi Ashutosh</creator><creator>BEN-ZION, Dolitzky</creator><creator>RAJARAM, Bodkhe Arjun</creator><creator>SRIHARI, Samala Rajamouli</creator><creator>LUTHRA, Parven Kumar</creator><creator>MUTHUSAMY, Anantha Rajmohan</creator><creator>SINGH, Amit</creator><creator>SHIVAJI, Mane Ganesh</creator><scope>EVB</scope></search><sort><creationdate>20191218</creationdate><title>PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SOLID STATE FORMS OF REMIMAZOLAM SALTS</title><author>MARIOARA, Mendelovici ; VIJAY, Joshi Ashutosh ; BEN-ZION, Dolitzky ; RAJARAM, Bodkhe Arjun ; SRIHARI, Samala Rajamouli ; LUTHRA, Parven Kumar ; MUTHUSAMY, Anantha Rajmohan ; SINGH, Amit ; SHIVAJI, Mane Ganesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3580219A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MARIOARA, Mendelovici</creatorcontrib><creatorcontrib>VIJAY, Joshi Ashutosh</creatorcontrib><creatorcontrib>BEN-ZION, Dolitzky</creatorcontrib><creatorcontrib>RAJARAM, Bodkhe Arjun</creatorcontrib><creatorcontrib>SRIHARI, Samala Rajamouli</creatorcontrib><creatorcontrib>LUTHRA, Parven Kumar</creatorcontrib><creatorcontrib>MUTHUSAMY, Anantha Rajmohan</creatorcontrib><creatorcontrib>SINGH, Amit</creatorcontrib><creatorcontrib>SHIVAJI, Mane Ganesh</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARIOARA, Mendelovici</au><au>VIJAY, Joshi Ashutosh</au><au>BEN-ZION, Dolitzky</au><au>RAJARAM, Bodkhe Arjun</au><au>SRIHARI, Samala Rajamouli</au><au>LUTHRA, Parven Kumar</au><au>MUTHUSAMY, Anantha Rajmohan</au><au>SINGH, Amit</au><au>SHIVAJI, Mane Ganesh</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SOLID STATE FORMS OF REMIMAZOLAM SALTS</title><date>2019-12-18</date><risdate>2019</risdate><abstract>The present disclosure relates to novel processes for the preparation of short acting benzodiazepines as well as to novel intermediates in this process. More particularly the disclosure relates to processes and intermediates for preparation of Methyl 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propanoate, commonly known as Remimazolam. The present disclosure also relates to solid state forms of Remimazolam salts, processes for the preparation thereof, pharmaceutical formulations / compositions thereof, and methods of use thereof.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3580219A1 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PROCESS FOR THE PREPARATION OF REMIMAZOLAM AND SOLID STATE FORMS OF REMIMAZOLAM SALTS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T18%3A26%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MARIOARA,%20Mendelovici&rft.date=2019-12-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3580219A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |