CURCUMIN-LOADED NANOEMULSIONS, METHOD OF MANUFACTURE, AND METHOD OF PREVENTIVE TREATMENT USING THE SAME

A oil-in-water curcumin nanoemulsion that includes curcumin dissolved in at least one miscible solvent and encapsulated in an oil core, wherein the oil core also comprises a stabilizer, wherein the oil core forms an organic phase which is dispersed in an aqueous solvent, and wherein the oil core is...

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Hauptverfasser: CONTRERAS ORELLANA, Pamela Paz, DIAZ GARCIA, Victor, LEYTON CAMPOS, Lisette, KOGAN BOCIAN, Marcelo Javier, LARA ARENAS, Pablo Alberto, OYARZUN AMPUERO, Felipe Andres, MIRANDA MIRANDA, Victor Andres, VIVANCO PALMA, Andrea I, CARDENAS OYARZO, Areli Marly, GUERRERO RIVERA, Simon Juan, QUEST, Andrew F. G
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creator CONTRERAS ORELLANA, Pamela Paz
DIAZ GARCIA, Victor
LEYTON CAMPOS, Lisette
KOGAN BOCIAN, Marcelo Javier
LARA ARENAS, Pablo Alberto
OYARZUN AMPUERO, Felipe Andres
MIRANDA MIRANDA, Victor Andres
VIVANCO PALMA, Andrea I
CARDENAS OYARZO, Areli Marly
GUERRERO RIVERA, Simon Juan
QUEST, Andrew F. G
description A oil-in-water curcumin nanoemulsion that includes curcumin dissolved in at least one miscible solvent and encapsulated in an oil core, wherein the oil core also comprises a stabilizer, wherein the oil core forms an organic phase which is dispersed in an aqueous solvent, and wherein the oil core is selected from a pharmaceutically acceptable oil. A method of manufacturing an oil-in-water curcumin nanoemulsion includes dissolving the curcumin in at least one miscible solvent; encapsulating the curcumin in the oil core to produce an organic phase solution; adding the stabilizer to the organic phase solution; dispersing the organic phase solution in the aqueous solvent; and evaporating the mixture. A method of preventing metastatic cancer using an oil-in-water curcumin nanoemulsion by administering an amount of the nanoemulsion topically to an area of an excised primary tumor, and monitoring any reincidence of metastatic cancer in the excised primary tumor area.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title CURCUMIN-LOADED NANOEMULSIONS, METHOD OF MANUFACTURE, AND METHOD OF PREVENTIVE TREATMENT USING THE SAME
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