IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF
The present invention is directed to immunoconjugates comprising an antibody or fragment thereof capable of specifically binding to "Disintegrin and Metalloproteinase Domain-containing Protein 9" ("ADAM9") conjugated to at least one pharmacological agent. The invention particular...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | DIEDRICH, Gundo SCRIBNER, Juniper A BARAT, Bhaswati BONVINI, Ezio HICKS, Stuart William LOO, Deryk YODER, Nicholas C JOHNSON, Leslie S |
| description | The present invention is directed to immunoconjugates comprising an antibody or fragment thereof capable of specifically binding to "Disintegrin and Metalloproteinase Domain-containing Protein 9" ("ADAM9") conjugated to at least one pharmacological agent. The invention particularly concerns such immunoconjugates that are cross-reactive with human ADAM9 and the ADAM9 of a non-human primate (e.g., a cynomolgus monkey). The invention additionally pertains to all such immunoconjugates that comprise a Light Chain Variable (VL) Domain and/or a Heavy Chain Variable (VH) Domain that has been humanized and/or deimmunized so as to exhibit reduced immunogenicity upon administration of such immunoconjugate to a recipient subject. The invention is also directed to pharmaceutical compositions that contain any of such immunoconjugates, and to methods involving the use of any of such immunoconjugates in the treatment of cancer and other diseases and conditions. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3558391B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3558391B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3558391B13</originalsourceid><addsrcrecordid>eNrjZLD29PUN9fN39vfzCnV3DHENVghxDHJ3DfH0c1dwdHH0tVRw9HNR8HUN8fB3CVbwd1MIDXZVCPFwDXL1d-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAcamphbGloZOhsZEKAEAj1wo3w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF</title><source>esp@cenet</source><creator>DIEDRICH, Gundo ; SCRIBNER, Juniper A ; BARAT, Bhaswati ; BONVINI, Ezio ; HICKS, Stuart William ; LOO, Deryk ; YODER, Nicholas C ; JOHNSON, Leslie S</creator><creatorcontrib>DIEDRICH, Gundo ; SCRIBNER, Juniper A ; BARAT, Bhaswati ; BONVINI, Ezio ; HICKS, Stuart William ; LOO, Deryk ; YODER, Nicholas C ; JOHNSON, Leslie S</creatorcontrib><description>The present invention is directed to immunoconjugates comprising an antibody or fragment thereof capable of specifically binding to "Disintegrin and Metalloproteinase Domain-containing Protein 9" ("ADAM9") conjugated to at least one pharmacological agent. The invention particularly concerns such immunoconjugates that are cross-reactive with human ADAM9 and the ADAM9 of a non-human primate (e.g., a cynomolgus monkey). The invention additionally pertains to all such immunoconjugates that comprise a Light Chain Variable (VL) Domain and/or a Heavy Chain Variable (VH) Domain that has been humanized and/or deimmunized so as to exhibit reduced immunogenicity upon administration of such immunoconjugate to a recipient subject. The invention is also directed to pharmaceutical compositions that contain any of such immunoconjugates, and to methods involving the use of any of such immunoconjugates in the treatment of cancer and other diseases and conditions.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220202&DB=EPODOC&CC=EP&NR=3558391B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220202&DB=EPODOC&CC=EP&NR=3558391B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DIEDRICH, Gundo</creatorcontrib><creatorcontrib>SCRIBNER, Juniper A</creatorcontrib><creatorcontrib>BARAT, Bhaswati</creatorcontrib><creatorcontrib>BONVINI, Ezio</creatorcontrib><creatorcontrib>HICKS, Stuart William</creatorcontrib><creatorcontrib>LOO, Deryk</creatorcontrib><creatorcontrib>YODER, Nicholas C</creatorcontrib><creatorcontrib>JOHNSON, Leslie S</creatorcontrib><title>IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF</title><description>The present invention is directed to immunoconjugates comprising an antibody or fragment thereof capable of specifically binding to "Disintegrin and Metalloproteinase Domain-containing Protein 9" ("ADAM9") conjugated to at least one pharmacological agent. The invention particularly concerns such immunoconjugates that are cross-reactive with human ADAM9 and the ADAM9 of a non-human primate (e.g., a cynomolgus monkey). The invention additionally pertains to all such immunoconjugates that comprise a Light Chain Variable (VL) Domain and/or a Heavy Chain Variable (VH) Domain that has been humanized and/or deimmunized so as to exhibit reduced immunogenicity upon administration of such immunoconjugate to a recipient subject. The invention is also directed to pharmaceutical compositions that contain any of such immunoconjugates, and to methods involving the use of any of such immunoconjugates in the treatment of cancer and other diseases and conditions.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD29PUN9fN39vfzCnV3DHENVghxDHJ3DfH0c1dwdHH0tVRw9HNR8HUN8fB3CVbwd1MIDXZVCPFwDXL1d-NhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAcamphbGloZOhsZEKAEAj1wo3w</recordid><startdate>20220202</startdate><enddate>20220202</enddate><creator>DIEDRICH, Gundo</creator><creator>SCRIBNER, Juniper A</creator><creator>BARAT, Bhaswati</creator><creator>BONVINI, Ezio</creator><creator>HICKS, Stuart William</creator><creator>LOO, Deryk</creator><creator>YODER, Nicholas C</creator><creator>JOHNSON, Leslie S</creator><scope>EVB</scope></search><sort><creationdate>20220202</creationdate><title>IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF</title><author>DIEDRICH, Gundo ; SCRIBNER, Juniper A ; BARAT, Bhaswati ; BONVINI, Ezio ; HICKS, Stuart William ; LOO, Deryk ; YODER, Nicholas C ; JOHNSON, Leslie S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3558391B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>DIEDRICH, Gundo</creatorcontrib><creatorcontrib>SCRIBNER, Juniper A</creatorcontrib><creatorcontrib>BARAT, Bhaswati</creatorcontrib><creatorcontrib>BONVINI, Ezio</creatorcontrib><creatorcontrib>HICKS, Stuart William</creatorcontrib><creatorcontrib>LOO, Deryk</creatorcontrib><creatorcontrib>YODER, Nicholas C</creatorcontrib><creatorcontrib>JOHNSON, Leslie S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DIEDRICH, Gundo</au><au>SCRIBNER, Juniper A</au><au>BARAT, Bhaswati</au><au>BONVINI, Ezio</au><au>HICKS, Stuart William</au><au>LOO, Deryk</au><au>YODER, Nicholas C</au><au>JOHNSON, Leslie S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF</title><date>2022-02-02</date><risdate>2022</risdate><abstract>The present invention is directed to immunoconjugates comprising an antibody or fragment thereof capable of specifically binding to "Disintegrin and Metalloproteinase Domain-containing Protein 9" ("ADAM9") conjugated to at least one pharmacological agent. The invention particularly concerns such immunoconjugates that are cross-reactive with human ADAM9 and the ADAM9 of a non-human primate (e.g., a cynomolgus monkey). The invention additionally pertains to all such immunoconjugates that comprise a Light Chain Variable (VL) Domain and/or a Heavy Chain Variable (VH) Domain that has been humanized and/or deimmunized so as to exhibit reduced immunogenicity upon administration of such immunoconjugate to a recipient subject. The invention is also directed to pharmaceutical compositions that contain any of such immunoconjugates, and to methods involving the use of any of such immunoconjugates in the treatment of cancer and other diseases and conditions.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3558391B1 |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T21%3A17%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=DIEDRICH,%20Gundo&rft.date=2022-02-02&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3558391B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |