GLYCO-ENGINEERED INTERLEUKIN-4 BASED ANTAGONISTS

GLYCO-ENGINEERED INTERLEUKIN-4 BASED ANTAGONISTS

The present invention relates to IL-4 muteins capable of inhibiting IL-4 and/or IL-13 signalling, wherein a non-protein-polymer is conjugated to the mutein via a mutated amino acid, which allows site-directed conjugation of a non-protein polymer. The present invention further relates to nucleic acid...

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Hauptverfasser: MÜLLER, Thomas Dieter, FIEBIG, Juliane E, SARAH K., Thomas
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator MÜLLER, Thomas Dieter
FIEBIG, Juliane E
SARAH K., Thomas
description The present invention relates to IL-4 muteins capable of inhibiting IL-4 and/or IL-13 signalling, wherein a non-protein-polymer is conjugated to the mutein via a mutated amino acid, which allows site-directed conjugation of a non-protein polymer. The present invention further relates to nucleic acids and vectors encoding the IL-4 muteins as well as pharmaceutical compositions, kit of parts comprising the IL-4 muteins. The invention further relates to the IL-4 muteins for use in methods of treatment.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title GLYCO-ENGINEERED INTERLEUKIN-4 BASED ANTAGONISTS
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