MET ANTIBODY DRUG CONJUGATES

Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs.

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Hauptverfasser: LI, Renhua, FENG, Yiqing, HIPSKIND, Philip Arthur, WILSON, Takako, LIU, Ling, WROBLESKI, Aaron David
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creator LI, Renhua
FENG, Yiqing
HIPSKIND, Philip Arthur
WILSON, Takako
LIU, Ling
WROBLESKI, Aaron David
description Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title MET ANTIBODY DRUG CONJUGATES
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