MESOPOROUS SILICA MATERIALS FOR THE CONTROLLED RELEASE OF ACTIVE SUBSTANCES AND THEIR APPLICATIONS

The present invention relates to a biomimetic system for the controlled release of essential oil components (EOCs) encapsulated in mesoporous silica nanoparticles, inspired by the natural plant-defence mechanisms and determined the antifungal activity of such systems. Delivery and antifungal studies...

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Bibliographische Detailangaben
Hauptverfasser:	KLOUCEK, Pavel, BOZIK, Matej, MARTINEZ MAÑEZ, Ramón, BERNARDOS BAU, Andrea
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The present invention relates to a biomimetic system for the controlled release of essential oil components (EOCs) encapsulated in mesoporous silica nanoparticles, inspired by the natural plant-defence mechanisms and determined the antifungal activity of such systems. Delivery and antifungal studies in the presence of Aspergillus niger have been carried out with mesoporous silica materials loaded with EOCs and capped with different saccharide gates - starch, maltodextrin, maltose and glucose. Sugar-capped systems show very low EOCs release in the absence of fungi, but displayed high cargo delivery in its presence. The anchored sugars were degraded by exogenous-enzymes from the fungi Aspergillus niger and the consequent release of the antifungal agent efficiently inhibited fungal growth. This invention shows an enzyme-induced antimicrobial delivery system using capped silica mesoporous nanoparticles.