BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS

The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to...

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Hauptverfasser: LEBECQUE, Serge, COSTE-INVERNIZZI, Isabelle, RENNO, Toufic, GIRAUD, Stéphane
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creator LEBECQUE, Serge
COSTE-INVERNIZZI, Isabelle
RENNO, Toufic
GIRAUD, Stéphane
description The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS
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