HUMAN STEM CELL DERIVED ENDOTHELIAL CELLS, ENDOTHELIAL- HEPATOCYTE CO-CULTURE SYSTEM AND USES THEREOF
The present disclosure provides a method of deriving endothelial cells, comprising (a) culturing lateral plate mesoderm cells under oxygen-deprived condition to obtain endothelial lineage cells; and (b) culturing endothelial cells from (a) on an extracellular matrix to maintain and expand the endoth...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NARMADA, Balakrishnan Chakrapani CHEUNG, Christine GOH, Yeek Teck |
| description | The present disclosure provides a method of deriving endothelial cells, comprising (a) culturing lateral plate mesoderm cells under oxygen-deprived condition to obtain endothelial lineage cells; and (b) culturing endothelial cells from (a) on an extracellular matrix to maintain and expand the endothelial lineage cells. Also disclosed herein is a cell co-culture system comprising an endothelial cell culture and a hepatocyte cell culture, as well as a microfluidic-based system comprising said cell co-culture system. Also disclosed herein is a method of disease modelling or drug testing using said cell co-culture system or said microfluidic-based system. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3458572A4</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3458572A4</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3458572A43</originalsourceid><addsrcrecordid>eNqNjL0KwjAYRbM4iPoO3wOYxbboGpJbUkiTkp9Cp1IkTqKF-v4oxcHR6cI5h7tlWadWWAoRLUkYQwq-6aEIVrmoYRphVhGOv4iTRieik0MEScdlMjF5UBjWJ2EVpYBAn9zD1Xu2uU33JR--u2NUI0rN8_wc8zJP1_zIrxFdUVaX6nwSZfFH8gb-8TRP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>HUMAN STEM CELL DERIVED ENDOTHELIAL CELLS, ENDOTHELIAL- HEPATOCYTE CO-CULTURE SYSTEM AND USES THEREOF</title><source>esp@cenet</source><creator>NARMADA, Balakrishnan Chakrapani ; CHEUNG, Christine ; GOH, Yeek Teck</creator><creatorcontrib>NARMADA, Balakrishnan Chakrapani ; CHEUNG, Christine ; GOH, Yeek Teck</creatorcontrib><description>The present disclosure provides a method of deriving endothelial cells, comprising (a) culturing lateral plate mesoderm cells under oxygen-deprived condition to obtain endothelial lineage cells; and (b) culturing endothelial cells from (a) on an extracellular matrix to maintain and expand the endothelial lineage cells. Also disclosed herein is a cell co-culture system comprising an endothelial cell culture and a hepatocyte cell culture, as well as a microfluidic-based system comprising said cell co-culture system. Also disclosed herein is a method of disease modelling or drug testing using said cell co-culture system or said microfluidic-based system.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200304&DB=EPODOC&CC=EP&NR=3458572A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76304</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200304&DB=EPODOC&CC=EP&NR=3458572A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NARMADA, Balakrishnan Chakrapani</creatorcontrib><creatorcontrib>CHEUNG, Christine</creatorcontrib><creatorcontrib>GOH, Yeek Teck</creatorcontrib><title>HUMAN STEM CELL DERIVED ENDOTHELIAL CELLS, ENDOTHELIAL- HEPATOCYTE CO-CULTURE SYSTEM AND USES THEREOF</title><description>The present disclosure provides a method of deriving endothelial cells, comprising (a) culturing lateral plate mesoderm cells under oxygen-deprived condition to obtain endothelial lineage cells; and (b) culturing endothelial cells from (a) on an extracellular matrix to maintain and expand the endothelial lineage cells. Also disclosed herein is a cell co-culture system comprising an endothelial cell culture and a hepatocyte cell culture, as well as a microfluidic-based system comprising said cell co-culture system. Also disclosed herein is a method of disease modelling or drug testing using said cell co-culture system or said microfluidic-based system.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwjAYRbM4iPoO3wOYxbboGpJbUkiTkp9Cp1IkTqKF-v4oxcHR6cI5h7tlWadWWAoRLUkYQwq-6aEIVrmoYRphVhGOv4iTRieik0MEScdlMjF5UBjWJ2EVpYBAn9zD1Xu2uU33JR--u2NUI0rN8_wc8zJP1_zIrxFdUVaX6nwSZfFH8gb-8TRP</recordid><startdate>20200304</startdate><enddate>20200304</enddate><creator>NARMADA, Balakrishnan Chakrapani</creator><creator>CHEUNG, Christine</creator><creator>GOH, Yeek Teck</creator><scope>EVB</scope></search><sort><creationdate>20200304</creationdate><title>HUMAN STEM CELL DERIVED ENDOTHELIAL CELLS, ENDOTHELIAL- HEPATOCYTE CO-CULTURE SYSTEM AND USES THEREOF</title><author>NARMADA, Balakrishnan Chakrapani ; CHEUNG, Christine ; GOH, Yeek Teck</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3458572A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>NARMADA, Balakrishnan Chakrapani</creatorcontrib><creatorcontrib>CHEUNG, Christine</creatorcontrib><creatorcontrib>GOH, Yeek Teck</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NARMADA, Balakrishnan Chakrapani</au><au>CHEUNG, Christine</au><au>GOH, Yeek Teck</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HUMAN STEM CELL DERIVED ENDOTHELIAL CELLS, ENDOTHELIAL- HEPATOCYTE CO-CULTURE SYSTEM AND USES THEREOF</title><date>2020-03-04</date><risdate>2020</risdate><abstract>The present disclosure provides a method of deriving endothelial cells, comprising (a) culturing lateral plate mesoderm cells under oxygen-deprived condition to obtain endothelial lineage cells; and (b) culturing endothelial cells from (a) on an extracellular matrix to maintain and expand the endothelial lineage cells. Also disclosed herein is a cell co-culture system comprising an endothelial cell culture and a hepatocyte cell culture, as well as a microfluidic-based system comprising said cell co-culture system. Also disclosed herein is a method of disease modelling or drug testing using said cell co-culture system or said microfluidic-based system.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3458572A4 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE |
| title | HUMAN STEM CELL DERIVED ENDOTHELIAL CELLS, ENDOTHELIAL- HEPATOCYTE CO-CULTURE SYSTEM AND USES THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T11%3A43%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NARMADA,%20Balakrishnan%20Chakrapani&rft.date=2020-03-04&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3458572A4%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |