METHOD FOR MANUFACTURING ACETAMINOPHEN PREPARATION

METHOD FOR MANUFACTURING ACETAMINOPHEN PREPARATION

The problem to be achieved by the present invention is to provide a method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable...

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Hauptverfasser: SAKAKIBARA, Kenji, KOMAI, Kunio, FUKUDA, Kiyoshi, SAKAMOTO, Hiroshi, BANBA, Hirokazu
Format: Patent
Sprache:eng ; fre ; ger
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator SAKAKIBARA, Kenji
KOMAI, Kunio
FUKUDA, Kiyoshi
SAKAMOTO, Hiroshi
BANBA, Hirokazu
description The problem to be achieved by the present invention is to provide a method for manufacturing a preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent elution properties, preferable hardness and high drug content uniformity, and a premix drug substance of acetaminophen which has improved manufacturability. According to the method of the present invention in which acetaminophen having a preset particle size is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed and manufacturing efficiency can be elevated. Thus, this method is highly useful for manufacturing an acetaminophen preparation having improved administrability, for example, a reduced size.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title METHOD FOR MANUFACTURING ACETAMINOPHEN PREPARATION
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