SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their pre...

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Hauptverfasser: NASVESCHUK, Chris G, HENDERSON, James A, LIANG, Yanke, LAZARSKI, Kiel, MICHAEL, Ryan E, PHILLIPS, Andrew J
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator NASVESCHUK, Chris G
HENDERSON, James A
LIANG, Yanke
LAZARSKI, Kiel
MICHAEL, Ryan E
PHILLIPS, Andrew J
description This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
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