HOMOGENEOUS ANTIBODY POPULATIONS

The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody...

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Bibliographische Detailangaben
Hauptverfasser:	Sun, Jeonghoon, Dillon, Thomas M, Vezina, Christopher John, Wypych, Jette, Ricci, Margaret Speed, Balland, Alain, Guo, Amy, Allen, Martin J, Bondarenko, Pavel, Shen, Wenyan
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.