METHOD FOR PRODUCING HYALURONIDASE CONJUGATE WITH POLYETHYLENEPIPERAZINE DERIVATIVES AND THE USE OF THE CONJUGATE PRODUCED
This invention relates to a method for obtaining immobilized enzyme preparations, in particular to preparation and application of noval active conjugate of enzyme with a polymer carrier. Said conjugate possesses the properties of Longidaza drug and inhibits hyperplasia of connective tissue, and anti...
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| creator | NEKRASOV, Arkadii Vasilevich KOZUKOV, Alexander Vladimirovich MEDVEDEV, Sergei Alekseevich KARAPUTADZE, Nino Temurievna KARAPUTADZE, Temuri Musaevich |
| description | This invention relates to a method for obtaining immobilized enzyme preparations, in particular to preparation and application of noval active conjugate of enzyme with a polymer carrier. Said conjugate possesses the properties of Longidaza drug and inhibits hyperplasia of connective tissue, and anti-inflammatory action, as well as it can be used for manufacturing stable, active and safe in use long-acting drugs in the form of a suppository, ointment, injection or cosmetic cream, and for making veterinary drugs. This method consists in conjugation of hyaluronidase with a water-soluble copolymer using carbodiimide or azide method. The conjugation is carried out with the use of copolymer N-oxide 1,4-ethylene piperazine, (N-carboxymethyl)-1,4-ethylene piperazine or its hydrazide, and 1,4-ethylene piperazine of general formula
where n is ranging from 40 % to 90 % of total number of cells;
m is ranging from 3 % to 40 % of total number of cells; n + m + 1 = 100 % , |
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where n is ranging from 40 % to 90 % of total number of cells;
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | METHOD FOR PRODUCING HYALURONIDASE CONJUGATE WITH POLYETHYLENEPIPERAZINE DERIVATIVES AND THE USE OF THE CONJUGATE PRODUCED |
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