PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer...

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Hauptverfasser: KRSKA, Shane, W, CHEN, Qinghao, STEWART, Gavin William, BAXTER, Carl, GIBB, Andrew, MALIGRES, Peter, E, SCOTT, Jeremy, TAN, Lushi
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Sprache:eng ; fre ; ger
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator KRSKA, Shane, W
CHEN, Qinghao
STEWART, Gavin William
BAXTER, Carl
GIBB, Andrew
MALIGRES, Peter, E
SCOTT, Jeremy
TAN, Lushi
description This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR MAKING M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
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