BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN WITH INCREASED SKIN CELL PROLIFERATION AND ANTI-OXIDATION EFFECT, AND COSMETIC COMPOSITION CONTAINING THE SAME AS EFFECTIVE COMPONENT
The present invention relates to a botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide seq...
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| creator | CHOI, Jong Nam KWON, Hyeong Il RYU, Han Bong LEE, Seong Ran CHOI, Tae Won LEE, Sun Kyo KIM, Tae Hyun JEONG, Tae Hwa |
| description | The present invention relates to a botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the botulinum toxin-human epidermal growth factor fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing a botulinum toxin-human epidermal growth factor fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for regenerating skin and improving skin wrinkle comprising, as an effective component, a botulinum toxin-human epidermal growth factor fusion protein, and as the cosmetic composition of the present invention has an effect of regenerating skin and improving skin wrinkle, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery. |
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fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180328&DB=EPODOC&CC=EP&NR=3299385A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180328&DB=EPODOC&CC=EP&NR=3299385A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHOI, Jong Nam</creatorcontrib><creatorcontrib>KWON, Hyeong Il</creatorcontrib><creatorcontrib>RYU, Han Bong</creatorcontrib><creatorcontrib>LEE, Seong Ran</creatorcontrib><creatorcontrib>CHOI, Tae Won</creatorcontrib><creatorcontrib>LEE, Sun Kyo</creatorcontrib><creatorcontrib>KIM, Tae Hyun</creatorcontrib><creatorcontrib>JEONG, Tae Hwa</creatorcontrib><title>BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN WITH INCREASED SKIN CELL PROLIFERATION AND ANTI-OXIDATION EFFECT, AND COSMETIC COMPOSITION CONTAINING THE SAME AS EFFECTIVE COMPONENT</title><description>The present invention relates to a botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the botulinum toxin-human epidermal growth factor fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing a botulinum toxin-human epidermal growth factor fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for regenerating skin and improving skin wrinkle comprising, as an effective component, a botulinum toxin-human epidermal growth factor fusion protein, and as the cosmetic composition of the present invention has an effect of regenerating skin and improving skin wrinkle, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjU1OAzEMhWfDApXewQdgFjBCokuTcToWiT1KPG13VVWlKwSVygk5GenPAbp48tN7n_Uem78PtSmwTBFMNyztMEUUoJF7ShEDLJOubQCPzjSBnzKrwJjUiAXWXCsWlwgz9ZA_a-YohDMQ2FNCO-MofZVxWxf6a0Tek7PnS-U0RzJ21cRRM18Ap2LIwrIEGwgyRgLMtz9e0RUWEntqHg67r1OZ3-6sAU_mhrYcf7bldNzty3f53dLYvS4W3fsbvnR3IP8PKE5Q</recordid><startdate>20180328</startdate><enddate>20180328</enddate><creator>CHOI, Jong Nam</creator><creator>KWON, Hyeong Il</creator><creator>RYU, Han Bong</creator><creator>LEE, Seong Ran</creator><creator>CHOI, Tae Won</creator><creator>LEE, Sun Kyo</creator><creator>KIM, Tae Hyun</creator><creator>JEONG, Tae Hwa</creator><scope>EVB</scope></search><sort><creationdate>20180328</creationdate><title>BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN WITH INCREASED SKIN CELL PROLIFERATION AND ANTI-OXIDATION EFFECT, AND COSMETIC COMPOSITION CONTAINING THE SAME AS EFFECTIVE COMPONENT</title><author>CHOI, Jong Nam ; 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPIRITS VINEGAR WINE |
| title | BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN WITH INCREASED SKIN CELL PROLIFERATION AND ANTI-OXIDATION EFFECT, AND COSMETIC COMPOSITION CONTAINING THE SAME AS EFFECTIVE COMPONENT |
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