COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENICE. COLI
Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenicE. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | TCHESNOKOVA, Veronika L KISIELA, Dagmara SOKURENKO, Evgeni V THOMAS, Wendy Evelyn |
| description | Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenicE. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenicE. coli, to treat a bacterial infection in subject in need thereof, and to treat or prevent inflammatory bowel disease (IBD), among other uses. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3294761A4</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3294761A4</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3294761A43</originalsourceid><addsrcrecordid>eNrjZPB19vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUggJcnUM8XX1CwHLBAS5hgHZQJUK_m4KoUH-AY5Ape6ufp7OrnoKzv4-njwMrGmJOcWpvFCam0HBzTXE2UM3tSA_PrW4IDE5NS-1JN41wNjI0sTczNDRxJgIJQCuHC4P</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENICE. COLI</title><source>esp@cenet</source><creator>TCHESNOKOVA, Veronika L ; KISIELA, Dagmara ; SOKURENKO, Evgeni V ; THOMAS, Wendy Evelyn</creator><creatorcontrib>TCHESNOKOVA, Veronika L ; KISIELA, Dagmara ; SOKURENKO, Evgeni V ; THOMAS, Wendy Evelyn</creatorcontrib><description>Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenicE. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenicE. coli, to treat a bacterial infection in subject in need thereof, and to treat or prevent inflammatory bowel disease (IBD), among other uses.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190403&DB=EPODOC&CC=EP&NR=3294761A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190403&DB=EPODOC&CC=EP&NR=3294761A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TCHESNOKOVA, Veronika L</creatorcontrib><creatorcontrib>KISIELA, Dagmara</creatorcontrib><creatorcontrib>SOKURENKO, Evgeni V</creatorcontrib><creatorcontrib>THOMAS, Wendy Evelyn</creatorcontrib><title>COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENICE. COLI</title><description>Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenicE. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenicE. coli, to treat a bacterial infection in subject in need thereof, and to treat or prevent inflammatory bowel disease (IBD), among other uses.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB19vcN8A_2DPH09wtWcPRzUfB1DfHwdwlWcPMPUggJcnUM8XX1CwHLBAS5hgHZQJUK_m4KoUH-AY5Ape6ufp7OrnoKzv4-njwMrGmJOcWpvFCam0HBzTXE2UM3tSA_PrW4IDE5NS-1JN41wNjI0sTczNDRxJgIJQCuHC4P</recordid><startdate>20190403</startdate><enddate>20190403</enddate><creator>TCHESNOKOVA, Veronika L</creator><creator>KISIELA, Dagmara</creator><creator>SOKURENKO, Evgeni V</creator><creator>THOMAS, Wendy Evelyn</creator><scope>EVB</scope></search><sort><creationdate>20190403</creationdate><title>COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENICE. COLI</title><author>TCHESNOKOVA, Veronika L ; KISIELA, Dagmara ; SOKURENKO, Evgeni V ; THOMAS, Wendy Evelyn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3294761A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>TCHESNOKOVA, Veronika L</creatorcontrib><creatorcontrib>KISIELA, Dagmara</creatorcontrib><creatorcontrib>SOKURENKO, Evgeni V</creatorcontrib><creatorcontrib>THOMAS, Wendy Evelyn</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TCHESNOKOVA, Veronika L</au><au>KISIELA, Dagmara</au><au>SOKURENKO, Evgeni V</au><au>THOMAS, Wendy Evelyn</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENICE. COLI</title><date>2019-04-03</date><risdate>2019</risdate><abstract>Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenicE. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenicE. coli, to treat a bacterial infection in subject in need thereof, and to treat or prevent inflammatory bowel disease (IBD), among other uses.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3294761A4 |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENICE. COLI |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T19%3A38%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=TCHESNOKOVA,%20Veronika%20L&rft.date=2019-04-03&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3294761A4%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |