IMIDAZOPYRIMIDINE AND IMIDAZOTRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME
A pharmaceutical composition for use in the prevention or treatment of disorder mediated by glutamate dysfunction and metabotropic glutamate receptor subtype 5 (mGluR5) comprising a therapeutically effective amount of a compound of the following Chemical Formula (1) or a pharmaceutically acceptable...
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| creator | JUNG, Hyo Jun PARK, Jong Sil HAN, Seung Nam HAM, Seung Mo RYU, Eun Ju KIM, Ji Yeon CHA, Soo Bong CHO, Nahm Ryune CHUNG, Jin Yong KIM, Yong Gil PARK, Chun Eung MAENG, Cheol Young SHIN, Yong Je JOUNG, Chan Mi LEE, Ju Young CHOI, Eun Ju JANG, Young Koo LEE, Ji Won MIN, Hye Kyung |
| description | A pharmaceutical composition for use in the prevention or treatment of disorder mediated by glutamate dysfunction and metabotropic glutamate receptor subtype 5 (mGluR5) comprising a therapeutically effective amount of a compound of the following Chemical Formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutically acceptable carrier or excipient:whereinX is CH or N;Z is O or S;R1 is aryl optionally substituted with one or more substituents selected from halo, hydroxy, alkyl, alkoxy, alkylthio, amino, dialkylamino, cyano, formyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carbamoyloxy alkyl, alkyl-C(O)O-alkyl, dialkylaminoalkyl and 5- or 6-membered heterocycloalkylalkyl; or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo, hydroxy, alkyl, alkoxy and haloalkyl; and R2 is aryl optionally substituted with one or more substituents selected from halo, deuterium, hydroxy and alkyl; or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo and alkyl. |
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or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo, hydroxy, alkyl, alkoxy and haloalkyl; and R2 is aryl optionally substituted with one or more substituents selected from halo, deuterium, hydroxy and alkyl; or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo and alkyl.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210106&DB=EPODOC&CC=EP&NR=3262047B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210106&DB=EPODOC&CC=EP&NR=3262047B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JUNG, Hyo Jun</creatorcontrib><creatorcontrib>PARK, Jong Sil</creatorcontrib><creatorcontrib>HAN, Seung Nam</creatorcontrib><creatorcontrib>HAM, Seung Mo</creatorcontrib><creatorcontrib>RYU, Eun Ju</creatorcontrib><creatorcontrib>KIM, Ji Yeon</creatorcontrib><creatorcontrib>CHA, Soo Bong</creatorcontrib><creatorcontrib>CHO, Nahm Ryune</creatorcontrib><creatorcontrib>CHUNG, Jin Yong</creatorcontrib><creatorcontrib>KIM, Yong Gil</creatorcontrib><creatorcontrib>PARK, Chun Eung</creatorcontrib><creatorcontrib>MAENG, Cheol Young</creatorcontrib><creatorcontrib>SHIN, Yong Je</creatorcontrib><creatorcontrib>JOUNG, Chan Mi</creatorcontrib><creatorcontrib>LEE, Ju Young</creatorcontrib><creatorcontrib>CHOI, Eun Ju</creatorcontrib><creatorcontrib>JANG, Young Koo</creatorcontrib><creatorcontrib>LEE, Ji Won</creatorcontrib><creatorcontrib>MIN, Hye Kyung</creatorcontrib><title>IMIDAZOPYRIMIDINE AND IMIDAZOTRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME</title><description>A pharmaceutical composition for use in the prevention or treatment of disorder mediated by glutamate dysfunction and metabotropic glutamate receptor subtype 5 (mGluR5) comprising a therapeutically effective amount of a compound of the following Chemical Formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient, together with a pharmaceutically acceptable carrier or excipient:whereinX is CH or N;Z is O or S;R1 is aryl optionally substituted with one or more substituents selected from halo, hydroxy, alkyl, alkoxy, alkylthio, amino, dialkylamino, cyano, formyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carbamoyloxy alkyl, alkyl-C(O)O-alkyl, dialkylaminoalkyl and 5- or 6-membered heterocycloalkylalkyl; or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo, hydroxy, alkyl, alkoxy and haloalkyl; and R2 is aryl optionally substituted with one or more substituents selected from halo, deuterium, hydroxy and alkyl; or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo and alkyl.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNik0KwjAQhbNxIeodcgFBW9H1mIxmwPyQTAt2U4rElWih3h9p6QFcve997y1FJksaGh_ucSRyKMFpOVuOBM3oNEaqganGNO3BQLSgsGJScJPK2-ATMXmXphIpkbtKNigTWFyLxbN7DXkz50rIC7Iy29x_2jz03SO_87fFUBbHYnc4nfflH5cfh0w1GA</recordid><startdate>20210106</startdate><enddate>20210106</enddate><creator>JUNG, Hyo Jun</creator><creator>PARK, Jong Sil</creator><creator>HAN, Seung Nam</creator><creator>HAM, Seung Mo</creator><creator>RYU, Eun Ju</creator><creator>KIM, Ji Yeon</creator><creator>CHA, Soo Bong</creator><creator>CHO, Nahm Ryune</creator><creator>CHUNG, Jin Yong</creator><creator>KIM, Yong Gil</creator><creator>PARK, Chun Eung</creator><creator>MAENG, Cheol Young</creator><creator>SHIN, Yong Je</creator><creator>JOUNG, Chan Mi</creator><creator>LEE, Ju Young</creator><creator>CHOI, Eun Ju</creator><creator>JANG, Young Koo</creator><creator>LEE, Ji Won</creator><creator>MIN, Hye Kyung</creator><scope>EVB</scope></search><sort><creationdate>20210106</creationdate><title>IMIDAZOPYRIMIDINE AND IMIDAZOTRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME</title><author>JUNG, Hyo Jun ; 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or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo, hydroxy, alkyl, alkoxy and haloalkyl; and R2 is aryl optionally substituted with one or more substituents selected from halo, deuterium, hydroxy and alkyl; or 5- to 12-membered, unsaturated heterocyclyl optionally substituted with one or more substituents selected from halo and alkyl.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | IMIDAZOPYRIMIDINE AND IMIDAZOTRIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME |
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