AUTOTAXIN INHIBITORY COMPOUNDS
The present invention relates to compounds of formula Iwherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; fre ; ger |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | HITCHIN, James HAMILTON, Niall MACDONALD, Ellen Catherine SHAH, Pritom STOCKLEY, Martin Lee JORDAN, Allan |
| description | The present invention relates to compounds of formula Iwherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP3253737B3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP3253737B3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP3253737B33</originalsourceid><addsrcrecordid>eNrjZJBzDA3xD3GM8PRT8PTz8HTyDPEPilRw9vcN8A_1cwnmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgHGRqbG5sbmTsbGRCgBAJyeIWU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>AUTOTAXIN INHIBITORY COMPOUNDS</title><source>esp@cenet</source><creator>HITCHIN, James ; HAMILTON, Niall ; MACDONALD, Ellen Catherine ; SHAH, Pritom ; STOCKLEY, Martin Lee ; JORDAN, Allan</creator><creatorcontrib>HITCHIN, James ; HAMILTON, Niall ; MACDONALD, Ellen Catherine ; SHAH, Pritom ; STOCKLEY, Martin Lee ; JORDAN, Allan</creatorcontrib><description>The present invention relates to compounds of formula Iwherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240529&DB=EPODOC&CC=EP&NR=3253737B3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240529&DB=EPODOC&CC=EP&NR=3253737B3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HITCHIN, James</creatorcontrib><creatorcontrib>HAMILTON, Niall</creatorcontrib><creatorcontrib>MACDONALD, Ellen Catherine</creatorcontrib><creatorcontrib>SHAH, Pritom</creatorcontrib><creatorcontrib>STOCKLEY, Martin Lee</creatorcontrib><creatorcontrib>JORDAN, Allan</creatorcontrib><title>AUTOTAXIN INHIBITORY COMPOUNDS</title><description>The present invention relates to compounds of formula Iwherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBzDA3xD3GM8PRT8PTz8HTyDPEPilRw9vcN8A_1cwnmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgHGRqbG5sbmTsbGRCgBAJyeIWU</recordid><startdate>20240529</startdate><enddate>20240529</enddate><creator>HITCHIN, James</creator><creator>HAMILTON, Niall</creator><creator>MACDONALD, Ellen Catherine</creator><creator>SHAH, Pritom</creator><creator>STOCKLEY, Martin Lee</creator><creator>JORDAN, Allan</creator><scope>EVB</scope></search><sort><creationdate>20240529</creationdate><title>AUTOTAXIN INHIBITORY COMPOUNDS</title><author>HITCHIN, James ; HAMILTON, Niall ; MACDONALD, Ellen Catherine ; SHAH, Pritom ; STOCKLEY, Martin Lee ; JORDAN, Allan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3253737B33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HITCHIN, James</creatorcontrib><creatorcontrib>HAMILTON, Niall</creatorcontrib><creatorcontrib>MACDONALD, Ellen Catherine</creatorcontrib><creatorcontrib>SHAH, Pritom</creatorcontrib><creatorcontrib>STOCKLEY, Martin Lee</creatorcontrib><creatorcontrib>JORDAN, Allan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HITCHIN, James</au><au>HAMILTON, Niall</au><au>MACDONALD, Ellen Catherine</au><au>SHAH, Pritom</au><au>STOCKLEY, Martin Lee</au><au>JORDAN, Allan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AUTOTAXIN INHIBITORY COMPOUNDS</title><date>2024-05-29</date><risdate>2024</risdate><abstract>The present invention relates to compounds of formula Iwherein A1, A2, A3, R1, R2, R3, R4, R5, R6, L, Ar and Q are each as defined herein. The compounds of the present invention are inhibitors of autotaxin (ATX) enzyme activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions (e.g. fibrosis) in which ATX activity is implicated.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; fre ; ger |
| recordid | cdi_epo_espacenet_EP3253737B3 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | AUTOTAXIN INHIBITORY COMPOUNDS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A16%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=HITCHIN,%20James&rft.date=2024-05-29&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP3253737B3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |