NUCLEOSIDE KINASE INHIBITORS

The present invention relates to method of inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, wherein the dash bond, X, R1, R2,...

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1. Verfasser:	SURLERAUX, Dominique
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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creator	SURLERAUX, Dominique
description	The present invention relates to method of inhibiting protein kinase activity which comprises contacting a protein kinase with a compound of formula (I), or the N-oxide, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or stereoisomer thereof, wherein the dash bond, X, R1, R2, R3, R4, R5, R6, R7, R8, and R9 are as defined in the claims. The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediated by a protein kinase selected from cancer, metabolic diseases, rheumatoid arthritis, psoriasis, inflammatory bowel disease, cardiovascular diseases, Vogt-Koyanagi-Harada syndrome (non-infectious blindness), and Alzheimer. The invention also provides a method for preparing the compounds of formula (I).
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The invention further relates to the compounds of formula (I) per se, as well as to their use as a medicament, and for use or in a method of treatment of a disease mediated by a protein kinase selected from cancer, metabolic diseases, rheumatoid arthritis, psoriasis, inflammatory bowel disease, cardiovascular diseases, Vogt-Koyanagi-Harada syndrome (non-infectious blindness), and Alzheimer. 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subjects	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
title	NUCLEOSIDE KINASE INHIBITORS
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