7-FLUORO-8-CHLORO-5 -DIBENZO[B,E][1,4]DIAZEPINE DERIVATIVES AND USE THEREOF

This invention relates to medicine, in particular to pharmacology and psychiatry, and can be used for the manufacture of medications for treatment of treatment-resistant forms of schizophrenia. For this purpose we proposed the use of compounds 11-(piperazine-1-yl)-7-fluoro-8-chloro-5H-dibenzo[b,e][1...

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Hauptverfasser:	MOROZOVA, Margarita Alekseevna, BENIASHVILI, Allan Gerovich, ZAPOLSKI, Maksim Eduardovich
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	MOROZOVA, Margarita Alekseevna BENIASHVILI, Allan Gerovich ZAPOLSKI, Maksim Eduardovich
description	This invention relates to medicine, in particular to pharmacology and psychiatry, and can be used for the manufacture of medications for treatment of treatment-resistant forms of schizophrenia. For this purpose we proposed the use of compounds 11-(piperazine-1-yl)-7-fluoro-8-chloro-5H-dibenzo[b,e][1,4]diazepine, 11-(4-methyl piperazine-1-yl)-7-fluoro-8-chloro-5H-dibenzo[b,e][1,4]diazepine, pharmaceutically acceptable salts, hydrates or solvates thereof. The invention allows developing an effective medication, the use of which in treatment of treatment-resistant forms of schizophrenia allows for eliminating both the positive and negative symptoms of schizophrenia, and cognitive disorders, and the use of which does not cause severe side effects that limit its use, including sedation, tachycardia, orthostatism, agranulocytosis and sialorrhea.
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The invention allows developing an effective medication, the use of which in treatment of treatment-resistant forms of schizophrenia allows for eliminating both the positive and negative symptoms of schizophrenia, and cognitive disorders, and the use of which does not cause severe side effects that limit its use, including sedation, tachycardia, orthostatism, agranulocytosis and sialorrhea.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170719&DB=EPODOC&CC=EP&NR=3192513A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170719&DB=EPODOC&CC=EP&NR=3192513A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MOROZOVA, Margarita Alekseevna</creatorcontrib><creatorcontrib>BENIASHVILI, Allan Gerovich</creatorcontrib><creatorcontrib>ZAPOLSKI, Maksim Eduardovich</creatorcontrib><title>7-FLUORO-8-CHLORO-5 -DIBENZO[B,E][1,4]DIAZEPINE DERIVATIVES AND USE THEREOF</title><description>This invention relates to medicine, in particular to pharmacology and psychiatry, and can be used for the manufacture of medications for treatment of treatment-resistant forms of schizophrenia. 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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	7-FLUORO-8-CHLORO-5 -DIBENZO[B,E][1,4]DIAZEPINE DERIVATIVES AND USE THEREOF
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