ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein,...
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| creator | JENSEN, Anne Elisabeth Carvalho OLSON, Kate GARCIA-MARTINEZ, Leon LATHAM, John DUTZAR, Ben OJALA, Ethan KOVACEVICH, Brian SMITH, Jeffrey T.I |
| description | The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing. |
| format | Patent |
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Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190327&DB=EPODOC&CC=EP&NR=3187506B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190327&DB=EPODOC&CC=EP&NR=3187506B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JENSEN, Anne Elisabeth Carvalho</creatorcontrib><creatorcontrib>OLSON, Kate</creatorcontrib><creatorcontrib>GARCIA-MARTINEZ, Leon</creatorcontrib><creatorcontrib>LATHAM, John</creatorcontrib><creatorcontrib>DUTZAR, Ben</creatorcontrib><creatorcontrib>OJALA, Ethan</creatorcontrib><creatorcontrib>KOVACEVICH, Brian</creatorcontrib><creatorcontrib>SMITH, Jeffrey T.I</creatorcontrib><title>ANTIBODIES TO IL-6 AND USE THEREOF</title><description>The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. 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These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBy9AvxdPJ38XQNVgjxV_D00TVTcPRzUQgNdlUI8XANcvV342FgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8a4BxoYW5qYGZk6GxkQoAQDGgyGZ</recordid><startdate>20190327</startdate><enddate>20190327</enddate><creator>JENSEN, Anne Elisabeth Carvalho</creator><creator>OLSON, Kate</creator><creator>GARCIA-MARTINEZ, Leon</creator><creator>LATHAM, John</creator><creator>DUTZAR, Ben</creator><creator>OJALA, Ethan</creator><creator>KOVACEVICH, Brian</creator><creator>SMITH, Jeffrey T.I</creator><scope>EVB</scope></search><sort><creationdate>20190327</creationdate><title>ANTIBODIES TO IL-6 AND USE THEREOF</title><author>JENSEN, Anne Elisabeth Carvalho ; OLSON, Kate ; GARCIA-MARTINEZ, Leon ; LATHAM, John ; DUTZAR, Ben ; OJALA, Ethan ; KOVACEVICH, Brian ; SMITH, Jeffrey T.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3187506B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>JENSEN, Anne Elisabeth Carvalho</creatorcontrib><creatorcontrib>OLSON, Kate</creatorcontrib><creatorcontrib>GARCIA-MARTINEZ, Leon</creatorcontrib><creatorcontrib>LATHAM, John</creatorcontrib><creatorcontrib>DUTZAR, Ben</creatorcontrib><creatorcontrib>OJALA, Ethan</creatorcontrib><creatorcontrib>KOVACEVICH, Brian</creatorcontrib><creatorcontrib>SMITH, Jeffrey T.I</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JENSEN, Anne Elisabeth Carvalho</au><au>OLSON, Kate</au><au>GARCIA-MARTINEZ, Leon</au><au>LATHAM, John</au><au>DUTZAR, Ben</au><au>OJALA, Ethan</au><au>KOVACEVICH, Brian</au><au>SMITH, Jeffrey T.I</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIBODIES TO IL-6 AND USE THEREOF</title><date>2019-03-27</date><risdate>2019</risdate><abstract>The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V H , V L and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | ANTIBODIES TO IL-6 AND USE THEREOF |
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