CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES
The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral a...
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| creator | WOO, Byoung Young SHIN, Kwang-Hyun CHOI, Gyeyoung CHO, Wonkyung PARK, Young-Ho JUNG, Kyoungmi LEE, Ki-Wha PARK, Miyoung CHOI, Joonho |
| description | The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O' -diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O' -di- p -toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity. |
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Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB39vAMcvRRCHIN9vcJDfH091PwdQ3x8HdR8HdT8NONNtHVMNR19PX08weKRvpo6gZ4uPpF-sTqBof6uPn7AWVcXBVcXIM8wxxDPMNcg3kYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgLGhmZG5pbGjiTERSgDrVi6D</recordid><startdate>20180103</startdate><enddate>20180103</enddate><creator>WOO, Byoung Young</creator><creator>SHIN, Kwang-Hyun</creator><creator>CHOI, Gyeyoung</creator><creator>CHO, Wonkyung</creator><creator>PARK, Young-Ho</creator><creator>JUNG, Kyoungmi</creator><creator>LEE, Ki-Wha</creator><creator>PARK, Miyoung</creator><creator>CHOI, Joonho</creator><scope>EVB</scope></search><sort><creationdate>20180103</creationdate><title>CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES</title><author>WOO, Byoung Young ; SHIN, Kwang-Hyun ; CHOI, Gyeyoung ; CHO, Wonkyung ; PARK, Young-Ho ; JUNG, Kyoungmi ; LEE, Ki-Wha ; PARK, Miyoung ; CHOI, Joonho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP3162793A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2018</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>WOO, Byoung Young</creatorcontrib><creatorcontrib>SHIN, Kwang-Hyun</creatorcontrib><creatorcontrib>CHOI, Gyeyoung</creatorcontrib><creatorcontrib>CHO, Wonkyung</creatorcontrib><creatorcontrib>PARK, Young-Ho</creatorcontrib><creatorcontrib>JUNG, Kyoungmi</creatorcontrib><creatorcontrib>LEE, Ki-Wha</creatorcontrib><creatorcontrib>PARK, Miyoung</creatorcontrib><creatorcontrib>CHOI, Joonho</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WOO, Byoung Young</au><au>SHIN, Kwang-Hyun</au><au>CHOI, Gyeyoung</au><au>CHO, Wonkyung</au><au>PARK, Young-Ho</au><au>JUNG, Kyoungmi</au><au>LEE, Ki-Wha</au><au>PARK, Miyoung</au><au>CHOI, Joonho</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES</title><date>2018-01-03</date><risdate>2018</risdate><abstract>The present specification relates to a chiral resolution method of a stereoisomer mixture, comprising a step of mixing a stereoisomer mixture of compounds, in which an amine group is bound to an asymmetric carbon atom, with a chiral auxiliary and salt-forming auxiliary compound, wherein the chiral auxiliary is an O,O' -diacyltartaric acid derivative, more specifically, a 2,3-dibenzoyl-tartaric acid or O,O' -di- p -toluoyl tartaric acid, the salt-forming auxiliary compound is mandelic acid or camphorsulfonic acid, and an optical isomer having a high level of optical purity can be obtained by using the method. Therefore, according to one aspect of the present invention, the method can be useful in pharmaceutical or cosmetic field when preparing an optical isomer having a high optical purity.</abstract><oa>free_for_read</oa></addata></record> |
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| title | CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES |
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