HIV PROTEASE INHIBITORS
The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibit...
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| creator | SIVALENKA, Vijayasaradhi BENNETT, David Jonathan LESSARD, Stephanie WILLIAMS, Peter, D MCCAULEY, John, A BEAULIEU, Christian MOLINARO, Carmela GRESHOCK, Thomas, J MORADEI, Oscar Miguel TRUONG, Vouy Linh BUNGARD, Christopher, J TUMMANAPALLI, Satyanarayana HOLLOWAY, M. Katharine MCKAY, Daniel CRANE, Sheldon |
| description | The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. |
| format | Patent |
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Katharine ; MCKAY, Daniel ; CRANE, Sheldon</creator><creatorcontrib>SIVALENKA, Vijayasaradhi ; BENNETT, David Jonathan ; LESSARD, Stephanie ; WILLIAMS, Peter, D ; MCCAULEY, John, A ; BEAULIEU, Christian ; MOLINARO, Carmela ; GRESHOCK, Thomas, J ; MORADEI, Oscar Miguel ; TRUONG, Vouy Linh ; BUNGARD, Christopher, J ; TUMMANAPALLI, Satyanarayana ; HOLLOWAY, M. Katharine ; MCKAY, Daniel ; CRANE, Sheldon</creatorcontrib><description>The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180221&DB=EPODOC&CC=EP&NR=3113780A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180221&DB=EPODOC&CC=EP&NR=3113780A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIVALENKA, Vijayasaradhi</creatorcontrib><creatorcontrib>BENNETT, David Jonathan</creatorcontrib><creatorcontrib>LESSARD, Stephanie</creatorcontrib><creatorcontrib>WILLIAMS, Peter, D</creatorcontrib><creatorcontrib>MCCAULEY, John, A</creatorcontrib><creatorcontrib>BEAULIEU, Christian</creatorcontrib><creatorcontrib>MOLINARO, Carmela</creatorcontrib><creatorcontrib>GRESHOCK, Thomas, J</creatorcontrib><creatorcontrib>MORADEI, Oscar Miguel</creatorcontrib><creatorcontrib>TRUONG, Vouy Linh</creatorcontrib><creatorcontrib>BUNGARD, Christopher, J</creatorcontrib><creatorcontrib>TUMMANAPALLI, Satyanarayana</creatorcontrib><creatorcontrib>HOLLOWAY, M. Katharine</creatorcontrib><creatorcontrib>MCKAY, Daniel</creatorcontrib><creatorcontrib>CRANE, Sheldon</creatorcontrib><title>HIV PROTEASE INHIBITORS</title><description>The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. 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Katharine</creatorcontrib><creatorcontrib>MCKAY, Daniel</creatorcontrib><creatorcontrib>CRANE, Sheldon</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIVALENKA, Vijayasaradhi</au><au>BENNETT, David Jonathan</au><au>LESSARD, Stephanie</au><au>WILLIAMS, Peter, D</au><au>MCCAULEY, John, A</au><au>BEAULIEU, Christian</au><au>MOLINARO, Carmela</au><au>GRESHOCK, Thomas, J</au><au>MORADEI, Oscar Miguel</au><au>TRUONG, Vouy Linh</au><au>BUNGARD, Christopher, J</au><au>TUMMANAPALLI, Satyanarayana</au><au>HOLLOWAY, M. Katharine</au><au>MCKAY, Daniel</au><au>CRANE, Sheldon</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HIV PROTEASE INHIBITORS</title><date>2018-02-21</date><risdate>2018</risdate><abstract>The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z1, Z2, V1, V2, V3, R6, R6A, and X are defined herein. The invention also relates to methods of using the 2,6-morpholine derivatives of the invention for the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | HIV PROTEASE INHIBITORS |
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