PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE

PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE

The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and...

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Hauptverfasser: PLUSCHKE, GERD, GEIB, NINA, GHASPARIAN, ARIN, JUD, MAJA, MARRERO NODARSE, ANIEBRYS, ROBINSON, JOHN ANTHONY, TAMBORINI, MARCO, ZUNIGA, ARMANDO
Format: Patent
Sprache:eng ; fre ; ger
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator PLUSCHKE, GERD
GEIB, NINA
GHASPARIAN, ARIN
JUD, MAJA
MARRERO NODARSE, ANIEBRYS
ROBINSON, JOHN ANTHONY
TAMBORINI, MARCO
ZUNIGA, ARMANDO
description The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
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subjects CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PROLINE-RICH PEPTIDES PROTECTIVE AGAINST S. PNEUMONIAE
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